YAP and TAZ Take Center Stage in Cancer
YAP and TAZ Take Center Stage in Cancer
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DOI：
10.1021/acs.biochem.5b01014
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发表时间：
2015-11-03
期刊：
影响因子：
2.9
通讯作者：
Hong, Wei
中科院分区：
文献类型：
--
作者：
Zhang, Kun;Qi, Hai-Xia;Hong, Wei
Hippo通路最初是通过筛选果蝇中的突变来鉴定和命名的，并且Hippo通路的核心组分在哺乳动物中高度保守。在Hippo通路中，MST 1/2和LATS 1/2调节下游转录共激活因子雅普和TAZ，其主要与TEAD家族转录因子相互作用以促进组织增殖、正常和癌症干细胞的自我更新、迁移和致癌。Hippo通路最初被认为是非常简单的;然而，最近的研究表明，雅普/TAZ是由多个信号通路组成的网络的一个组成部分和连接点。本文就雅普/TAZ的上下游事件及其调控途径的最新研究进展作一综述。此外，我们还关注了Hippo通路与其他肿瘤相关通路之间的串扰，并讨论了它们作为治疗靶点的潜力。
The Hippo pathway was originally identified and named through screening for mutations in Drosophila, and the core components of the Hippo pathway are highly conserved in mammals. In the Hippo pathway, MST1/2 and LATS1/2 regulate downstream transcription coactivators YAP and TAZ, which mainly interact with TEAD family transcription factors to promote tissue proliferation, self-renewal of normal and cancer stem cells, migration, and carcinogenesis. The Hippo pathway was initially thought to be quite straightforward; however, recent studies have revealed that YAP/TAZ is an integral part and a nexus of a network composed of multiple signaling pathways. Therefore, in this review, we will summarize the latest findings on events upstream and downstream of YAP/TAZ and the ways of regulation of YAP/TAZ. In addition, we also focus on the crosstalk between the Hippo pathway and other tumor-related pathways and discuss their potential as therapeutic targets.