A cross-sectional study of HIV and tuberculosis coinfection cases in mainland China
A cross-sectional study of HIV and tuberculosis coinfection cases in mainland China
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DOI：
10.1097/smj.0b013e31817c13ab
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发表时间：
2008-09-01
影响因子：
1.1
通讯作者：
Cao, Yunzhen
中科院分区：
文献类型：
--
作者：
Jiang Xueyan;Lu Hongzhou;Cao, Yunzhen
工作背景：艾滋病和结核病在中国大陆的流行是前所未有的，这两种传染病的交汇日益严重地危及人类健康和社会经济发展。迄今为止，中国大陆HIV/TB合并感染病例的临床表现、实验室表现和表皮学特征尚未详细描述。为了评估HIV和TB合并感染的发病率、临床特征和转归，我们对中国大陆境内医院报告的HIV和TB合并感染病例进行了横断面研究。方法：在2003年1月至2005年12月的3年调查期间，对所有患者进行定期随访。结果：共241例（男183例，女58例）肺结核、肺外结核或肺结核合并肺结核，分别占9.5%、21.6%和18.7%。在报告的241例HIV/TB合并感染病例中，76.8%的CD 4细胞计数200/mm（3），58.5%的CD 4细胞计数100/mm（3）。结核病和艾滋病病毒的治疗提供给患者和死亡率归因于合并感染的cases.Conclusions：HIV/TB合并感染的临床特征不同的241例研究与肺结核为主。大多数患者的免疫功能受到抑制，基于CD 4 + T细胞计数减少。HIV/TB合并感染与高死亡率相关，即使提供HAART和/或TB药物治疗。需要更多的敏感技术来改善艾滋病毒/结核病合并感染的诊断。
Background: The prevalence of HIV/AIDS and tuberculosis (TB) within mainland China is unprecedented and the convergence of these two infectious diseases is increasingly and significantly endangering human health for socioeconomic development. To date, the clinical manifestations, laboratory presentation, and epidermologic features of HIV/TB coinfection cases in mainland China have not been described in detail. To assess the incidence, clinical characteristics and outcome of coinfection with HIV and TB, we conducted a cross-sectional study of coinfected cases reported front mile domestic hospitals throughout mainland China.Method: During the 3-year survey period from January 2003 to December 2005, all patients were followed regularly. Medical records were reviewed, a standardized questionnaire was administered, and clinical databases were analyzed.Results: A total of 241 cases (183 male, 58 female) with pulmonary TB, extrapulmonary TB, or both, accounted for 9.5%, 21.6%, and 18.7% of cases, respectively. Among the 241 reported cases of HIV/TB coinfection, 76.8% had CD4 cell counts 200/mm(3) and 58.5% were 100/mm(3). Treatments for TB and HIV were provided to patients and mortality attributable to coinfection was reported for 15.8% of the cases.Conclusions: The clinical characteristics of HIV/TB coinfection varied among the 241 cases studied with pulmonary TB predominating. Immune function among most patients was suppressed based on reduced CD4+ T cell counts. HIV/TB coinfection was related to high mortality even when HAART and/or drug therapy for TB was provided. Additional sensitive techniques are needed to improve the diagnosis of HIV/TB coinfection.