Regional distribution of muscarinic receptors preferring gallamine in the rat brain.
Regional distribution of muscarinic receptors preferring gallamine in the rat brain.
复制标题
大鼠脑中毒蕈碱受体偏好没食子胺的区域分布。
DOI：
10.1016/0006-2952(86)90692-1
复制
发表时间：
1986
影响因子：
5.8
通讯作者：
W. Hoss
中科院分区：
文献类型：
--
作者：
M. Price;W. Messer;W. Hoss
The regional distribution of muscarinic receptors recognized by the antagonist gallamine was determined autoradiographically by the ability of gallamine to reduce the binding of [3H]quinuclidinyl benzilate in rat brain slices. The inhibition data obtained from indirect binding assays on whole slices indicated that gallamine distinguished at least two sites with differing affinities. Analysis using a two-site model gaveKh= 0.6μM,K1= 10μM. The regions of highest and lowest affinity for gallamine were apparent qualitatively by visual inspection of the autoradiograms. A number of regions in coronal sections at three different levels were compared by microdensitometry. Gallamine possessed greater overall affinity for the diencephalon and brainstem than for the forebrain. Within the forebrain, the septal nucleus was unique in that it displayed high affinity for gallamine. Within the brainstem, the superior colliculus had the greatest proportion of sites with high affinity for gallamine. In general, the binding profile of gallamine was opposite to that of the antagonist pirenzepine and similar to that of the agonist carbachol, suggesting that gallamine is selective for M2 muscarinic receptors.
没食子胺与大脑毒蕈碱受体相互作用的表征。
影响因子：
5.8
作者：
Ellis,J;Lenox,RH
通讯作者：
Lenox,RH
经典毒蕈碱拮抗剂的四元形式区分毒蕈碱受体亚群：与没食子胺定义的亚群的相关性。
DOI：
10.1016/0006-291x(85)90319-5
发表时间：
1985
影响因子：
3.1
作者：
Ellis,J;Lenox,RH
通讯作者：
Lenox,RH