Epidemiologic evidence for the fetal overnutrition hypothesis: Findings from the Mater-University Study of Pregnancy and its outcomes
Epidemiologic evidence for the fetal overnutrition hypothesis: Findings from the Mater-University Study of Pregnancy and its outcomes
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DOI：
10.1093/aje/kwk030
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发表时间：
2007-02-15
影响因子：
5
通讯作者：
Najman, Jake M.
中科院分区：
文献类型：
--
作者：
Lawlor, Debbie A.;Smith, George Davey;Najman, Jake M.
胎儿营养过剩假说认为，母亲肥胖程度越高，后代一生中的肥胖程度就会越高。作者研究了父母孕前体重指数（BMI;体重（kg）/身高（m）（2）），基于母亲在其第一次产前诊所就诊时报告的身高和体重，以及来自澳大利亚布里斯班出生队列的3，340名父母-子女三人组的后代BMI（14岁时测量的身高和体重）（母亲于1981-1984年招募）。母亲与子女的BMI关联强于父亲与子女的BMI关联。在完全校正的模型中，母亲BMI增加一个标准差（SD），14岁时标准化后代BMI的增加为0.362 SD（95%置信区间：0.323，0.402），父亲BMI增加一个SD的相应结果为0.239 SD（95%置信区间：0.197，0.282）。在所有混杂因素校正模型中，母亲-子女BMI和父亲-子女BMI之间的关联程度差异有统计学支持（所有p < 0.0001）。在敏感性分析中，考虑到不同的非亲子关系的合理水平（高达15%），更大的母亲的影响仍然存在。这些发现为胎儿营养过剩假说提供了一些支持。
The fetal overnutrition hypothesis proposes that greater maternal adiposity results in increased obesity throughout life in the offspring. The authors examined the associations between parental prepregnancy body mass index (BMI; weight (kg)/height (m)(2)), based on height and weight reported by the mother at her first antenatal clinic visit, and offspring BMI (height and weight measured at age 14 years) in 3,340 parent-offspring trios from a birth cohort based in Brisbane, Australia (mothers were recruited in 1981-1984). The maternal-offspring BMI association was stronger than the paternal-offspring BMI association. In the fully adjusted model, the increase in standardized offspring BMI at age 14 for a one-standard-deviation (SD) increase in maternal BMI was 0.362 SD (95% confidence interval: 0.323, 0.402), and the corresponding result for a one-SD increase in paternal BMI was 0.239 SD (95% confidence interval: 0.197, 0.282). There was statistical support for a difference in the magnitude of the association between maternal-offspring BMI and paternal-offspring BMI in all confounder-adjusted models tested (all p's < 0.0001). In sensitivity analyses taking account of different plausible levels of nonpaternity (up to 15%), the greater maternal effect remained. These findings provide some support for the fetal overnutrition hypothesis.