Effects of diabetes mellitus on amyotrophic lateral sclerosis: a systematic review.
Effects of diabetes mellitus on amyotrophic lateral sclerosis: a systematic review.
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DOI：
10.1186/1756-0500-7-171
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发表时间：
2014-03-24
影响因子：
1.8
通讯作者：
Kengne AP
中科院分区：
文献类型：
--
作者：
Lekoubou A;Matsha TE;Sobngwi E;Kengne AP
肌萎缩侧索硬化症（amyotrophiclateralsclerosis，ALS）是一种难以治愈的运动神经元退行性疾病，其发病和病程可能受并发糖尿病（diabetesmellitus，DM）的影响。我们进行了一项系统评价，以评估DM/血糖异常状态对ALS的影响。我们检索了PubMed MEDLINE，从成立到2013年3月，以英语和法语发表的关于DM（和相关状态）和ALS的原始文章。我们对每个研究设计没有限制。7项研究/1410篇引文（5项病例对照和2项横断面）被纳入最终选择。ALS患者的人数从18人到2371人不等。在3项和2项病例对照研究中，关注的结局分别为ALS和DM/血糖异常状态。DM/糖耐量受损状态不影响ALS参与者的疾病进展、生存率、疾病严重程度和疾病持续时间，但在一项研究中发现患有DM的ALS参与者年龄较大。ALS和非ALS参与者的DM/IGT患病率相似。由于缺乏前瞻性队列研究以及ALS和DM诊断标准的异质性，本综述受到限制。这一系统性综述表明，ALS和DM相关性的证据相当有限，并且来自横断面研究。需要进行前瞻性研究，辅以ALS登记和动物研究，以更好地了解这两种情况之间的关系。
Amyotrophic lateral sclerosis (ALS) is an incurable motor neuron degenerative disease which onset and course may be affected by concurrent diabetes mellitus (DM). We performed a systematic review to assess the effect of DM/dysglycemic states on ALS. We searched PubMed MEDLINE, from inception to March 2013 for original articles published in English and in French languages on DM (and related states) and ALS. We made no restriction per study designs. Seven studies/1410 citations (5 case–control and 2 cross-sectional) were included in the final selection. The number of participants with ALS ranged from 18 to 2371. The outcome of interest was ALS and DM/dysglycemic states respectively in three and two case control-studies. DM/impaired glucose tolerance status did not affect disease progression, survival, disease severity and disease duration in ALS participants but ALS participants with DM were found to be older in one study. DM/IGT prevalence was similar in both ALS and non ALS participants. This review was limited by the absence of prospective cohort studies and the heterogeneity in ALS and DM diagnosis criteria. This systematic review suggests that evidences for the association of ALS and DM are rather limited and derived from cross-sectional studies. Prospective studies supplemented by ALS registries and animal studies are needed to better understand the relationship between both conditions.