MCelsrl is an evolutionarily conserved seven-pass transmembrane receptor and is expressed during mouse embryonic development
MCelsrl is an evolutionarily conserved seven-pass transmembrane receptor and is expressed during mouse embryonic development
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DOI：
10.1016/s0925-4773(98)00153-1
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发表时间：
1998-11-01
影响因子：
2.6
通讯作者：
Little, PFR
中科院分区：
文献类型：
--
作者：
Hadjantonakis, AK;Formstone, CJ;Little, PFR
Mcelsr1编码一个由3034个氨基酸组成的蛋白质，预计包含7个跨膜结构域，与一组与肽激素结合的G蛋白偶联受体同源。其胞外结构域包括表皮生长因子样重复序列、层粘连蛋白A G结构域和钙粘附素重复序列。已在C、elegans和D.Blackogaster中发现了同源基因，这表明CelsR基因家族是古老的。MCelsr1mRNA在原肠胚形成之前表达，随后主要限于外胚层衍生物，并在发育中的中枢神经系统(CNS)中受到严格调控。我们观察到节段性受限基因在发育中的后脑和脊髓背腹侧动态受限的“条带”中的表达。(C)1998爱思唯尔爱尔兰科学有限公司。保留所有权利。
Mcelsr1 encodes a protein of 3034 amino acids predicted to contain seven membrane spanning domains having homology to a group of peptide hormone binding G-protein coupled receptors. Its extracellular domain comprises epidermal growth factor-like repeats, laminin A G-domains and cadherin repeats. Homologous genes have been identified in C, elegans and D. melanogaster suggesting that the Celsr gene family is ancient. mCelsr1 mRNA expression precedes gastrulation, is subsequently restricted primarily to ectodermal derivatives and is tightly regulated in the developing central nervous system (CNS). We observe segmentally-restricted gene expression in the developing hindbrain and in the spinal cord dynamic dorso-ventrally restricted 'stripes' of expression. (C) 1998 Elsevier Science Ireland Ltd. All rights reserved.