Similar T-cell oligoclonality in antimitochondrial antibody-positive and -negative primary biliary cirrhosis.
Similar T-cell oligoclonality in antimitochondrial antibody-positive and -negative primary biliary cirrhosis.
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抗线粒体抗体阳性和阴性的原发性胆汁性肝硬化中存在类似的 T 细胞寡克隆性。
DOI：
10.1023/a:1005609100900
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发表时间：
2001
影响因子：
3.1
通讯作者：
Combes,B
中科院分区：
文献类型：
--
作者：
Mayo,MJ;Lipsky,PE;Miller,SN;Stastny,P;Combes,B
大约5%的患者的临床和组织学特征提示原发性胆汁性肝硬化没有抗线粒体抗体，可以通过目前的方法检测。虽然这些自身抗体在肝脏疾病发病机制中的作用尚不确定，但门脉束内的T淋巴细胞被认为是胆管破坏的重要介质。为了研究一个类似的T细胞过程可能参与抗线粒体抗体阳性和阴性原发性胆汁性肝硬化的假设，我们的特点是寡克隆扩增的T细胞在这两种类型的患者通过分析互补决定区3的长度在外周血单核细胞。寡克隆扩增T细胞的分布在两组中相似。这一发现并不支持抗线粒体抗体阳性和阴性原发性胆汁性肝硬化的不同T细胞介导的发病机制，而是表明类似的过程可能参与两者的免疫发病机制。
Approximately 5% of patients with clinical and histological features suggestive of primary biliary cirrhosis do not have anti-mitochondrial antibodies that can be detected by current methodologies. Although the role of these autoantibodies in the pathogenesis of liver disease is uncertain, T lymphocytes within the portal tracts are felt to be important mediators of bile duct destruction. In order to investigate the hypothesis that a similar T-cell process may be involved in both antimitochondrial antibody-positive and -negative primary biliary cirrhosis, we characterized the oligoclonally expanded T cells in both types of patients by analysis of complementarity determining region 3 length in peripheral blood mononuclear cells. The distribution of oligoclonally expanded T cells was similar in both groups. This finding does not support a distinct T-cell-mediated pathogenesis for anti-mitochondrial antibody-positive and -negative primary biliary cirrhosis but rather suggests that similar processes may be involved in the immunopathogenesis of both.