Nuclear magnetic relaxation studies of the compartmentalized water in crosslinked polymer gels
Nuclear magnetic relaxation studies of the compartmentalized water in crosslinked polymer gels
复制标题
交联聚合物凝胶中分区水的核磁弛豫研究
DOI：
10.1002/mrm.1910090102
复制
发表时间：
1989
影响因子：
3.3
通讯作者：
Tokuko. Watanabe
中科院分区：
文献类型：
--
作者：
N. Murase;Tokuko. Watanabe
使用宽线质子脉冲NMR对由交联葡聚糖或聚丙烯酰胺制成的凝胶中的水（水含量，30 - 60重量%）进行核磁弛豫测量。T1和T2值都显示出对孔径的影响，即，由聚合物凝胶的交联形成的隔室的尺寸。对于具有小于临界尺寸的隔室的凝胶获得的T2（或T1）值在本实验中使用的水含量的范围内保持较低。另一方面，具有较大隔室的凝胶的那些值随着尺寸的增大而变高。当隔室的大小大于临界大小时，T1和T2值也随着含水量的增加而变高。拐点可以被认为对应于临界隔室大小，低于该临界隔室大小，凝胶中隔室化水的运动或多或少受到限制。然而，当隔室小时，不仅水的分子运动的影响，而且隔室化的水和凝胶基质或水合水之间的质子交换的影响，应考虑到所观察到的短弛豫时间的解释，特别是由T2。研究结果为解释和评价组织中的弛豫值提供了有用的信息。出版社：Academic Press，Inc.
Nuclear magnetic relaxation measurements of water in gels made of crosslinked dextran or polyacrylamide (water content, 30‐60 wt%) were carried out using broad‐line proton‐pulsed NMR. Both T1 and T2 values showed inflection against pore size, i.e., the size of the compartment made by crosslinks of the polymer gels. T2 (or T1) values obtained for gels with compartments smaller than the critical size remained low within the range of the water content used in this experiment. Those values of gels with larger compartments, on the other hand, became higher with increasing size. When the size of the compartment was larger than the critical size, T1 and T2 values also became higher with increasing water content. The inflection point can be considered to correspond to the critical compartment size below which the motion of compartmentalized water in gels is more or less restricted. When the compartment is small, however, not only the effect of the molecular motion of water but also that of the proton exchange between compartmentalized water and gel matrix or hydration water should be taken into consideration for the interpretation of the short relaxation times observed, especially by T2. The results obtained in this investigation might provide useful information in the explanation and evaluation of the relaxation values in tissue. © 1989 Academic Press, Inc.