POSTPRANDIAL GLUCOSE AND INSULIN RESPONSES TO MEALS CONTAINING DIFFERENT CARBOHYDRATES IN NORMAL AND DIABETIC SUBJECTS
POSTPRANDIAL GLUCOSE AND INSULIN RESPONSES TO MEALS CONTAINING DIFFERENT CARBOHYDRATES IN NORMAL AND DIABETIC SUBJECTS
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DOI：
10.1056/nejm198307073090102
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发表时间：
1983-01-01
影响因子：
158.5
通讯作者：
GOETZ, FC
中科院分区：
文献类型：
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作者：
BANTLE, JP;LAINE, DC;GOETZ, FC
为了研究饮食碳水化合物的形式是否会影响葡萄糖和胰岛素的反应，研究了10名健康受试者、12名I型糖尿病患者和10名II型糖尿病患者对5顿饭的葡萄糖和胰岛素反应，每顿饭都含有不同形式的碳水化合物，但总碳水化合物、蛋白质和脂肪的含量几乎相同。试验碳水化合物为葡萄糖、果糖、蔗糖、马铃薯淀粉和小麦淀粉。在所有三组中，以蔗糖为受试碳水化合物的膳食与以土豆、小麦或葡萄糖为受试碳水化合物的膳食相比，在血浆葡萄糖浓度峰值增量或血糖反应曲线下的面积没有显著增加。糖尿病患者的尿糖排泄量在蔗糖餐后并没有明显增加。含有果糖作为测试碳水化合物的膳食对血糖水平的影响最小，但差异并不总是在统计学上显著。在健康受试者和II型糖尿病患者中，血清胰岛素峰值浓度对5种碳水化合物的反应没有显著差异。这些数据不支持这样的观点，即当膳食蔗糖作为一餐的一部分摄入时，会加剧餐后高血糖。
To examine whether the form of dietary carbohydrate influences glucose and insulin responses, the glucose and insulin responses to 5 meals were studied, each containing a different form of carbohydrate but all with nearly identical amounts of total carbohydrate, protein and fat, in 10 healthy subjects, 12 patients with Type I diabetes and 10 patients with Type II diabetes. The test carbohydrates were glucose, fructose, sucrose, potato starch and wheat starch. In all 3 groups, the meal containing sucrose as the test carbohydrate did not produce significantly greater peak increments in the plasma concentration of glucose or greater increments in the area under the plasma glucose-response curves than did meals containing potato, wheat, or glucose as test carbohydrates. Urinary excretion of glucose in patients with diabetes was not significantly greater after the sucrose meal. The meal containing fructose as the test carbohydrate produced the smallest increments in plasma glucose levels, but the differences were not always statistically significant. In healthy subjects and patients with Type II diabetes, peak serum concentrations of insulin were not significantly different in response to the 5 test carbohydrates. The data do not support the view that dietary sucrose, when consumed as part of a meal, aggravates postprandial hyperglycemia.