Antiviral drugs specific for coronaviruses in preclinical development.
Antiviral drugs specific for coronaviruses in preclinical development.
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DOI：
10.1016/j.coviro.2014.06.002
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发表时间：
2014-10
影响因子：
5.9
通讯作者：
Sarafianos, Stefan G.
中科院分区：
文献类型：
--
作者：
Adedeji, Adeyemi O.;Sarafianos, Stefan G.
冠状病毒是一种会导致人类和动物全身疾病的RNA病毒。目前还没有获得批准的治疗冠状病毒感染的药物。已经确定了几种具有已知作用机制的SARS-CoV抑制剂。这些抑制剂是冠状病毒治疗的有希望的线索。冠状病毒是一种阳性链RNA病毒，在包括人类在内的许多物种中会导致呼吸道、肠道和中枢神经系统疾病。直到最近，这些病毒中的少数几种对人类造成的疾病负担相对较低，阻碍了冠状病毒特异性疗法的发展。然而，严重急性呼吸综合征冠状病毒(SARS-CoV)的出现，以及最近的中东呼吸综合征冠状病毒(MERS-CoV)的出现，推动了此类药物的发展。本文综述了一些新发现的SARS-CoV抑制剂，它们的作用机制已知，并具有抑制新型MERS-CoV的潜力。这些化合物的优化版本的临床开发可能有利于SARS-CoV、当前的MERS-CoV和未来其他类似SARS的流行病的治疗和控制。
Coronaviruses are RNA viruses that cause systemic diseases in humans and animals. There are no approved drugs for the treatment of coronavirus infections. Several SARS-CoV inhibitors, with known mechanisms of action, have been identified. These inhibitors stand as promising leads for coronavirus therapeutics. Coronaviruses are positive stranded RNA viruses that cause respiratory, enteric and central nervous system diseases in many species, including humans. Until recently, the relatively low burden of disease in humans caused by few of these viruses impeded the development of coronavirus specific therapeutics. However, the emergence of severe acute respiratory syndrome coronavirus (SARS-CoV), and more recently, Middle East respiratory syndrome coronavirus (MERS-CoV), has impelled the development of such drugs. This review focuses on some newly identified SARS-CoV inhibitors, with known mechanisms of action and their potential to inhibit the novel MERS-CoV. The clinical development of optimized versions of such compounds could be beneficial for the treatment and control of SARS-CoV, the current MERS-CoV and other future SARS-like epidemics.
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影响因子：
64.5
作者：
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通讯作者：
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影响因子：
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作者：
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作者：
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DOI：
10.1001/jama.289.21.joc30885
发表时间：
2003-06-04
影响因子：
120.7
作者：
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通讯作者：
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