Biology of Tumor Associated Macrophages in Diffuse Large B Cell Lymphoma
Biology of Tumor Associated Macrophages in Diffuse Large B Cell Lymphoma
复制标题
弥漫性大 B 细胞淋巴瘤中肿瘤相关巨噬细胞的生物学
DOI：
10.1089/dna.2018.4374
复制
发表时间：
2018-11-07
影响因子：
3.1
通讯作者：
Feng，Ru
中科院分区：
文献类型：
--
作者：
Huang，Weimin;Wei，Xiaolei;Feng，Ru
已知肿瘤相关微环境在不同恶性肿瘤的发展和进展过程中起着至关重要的作用。肿瘤相关巨噬细胞（tumor associated macrophages，TAMs）作为肿瘤微环境的一部分，对肿瘤细胞的发生、增殖、转移和存活起着至关重要的作用。近年来，越来越多的研究表明TAM与弥漫性大B细胞淋巴瘤（DLBCL）患者的不良临床状态和生存率有关。鉴于TAMs在DLBCL肿瘤微环境中的复杂作用，本文综述TAMs与DLBCL细胞的生物学机制，包括细胞外基质重塑和血管生成促进、肿瘤促进、免疫抑制和吞噬抑制。本综述有助于我们进一步了解TAMs对DLBCL的综合影响，并探索可能的预后标志物和治疗靶点。
The tumor associated microenvironment is known to play a vital role during the development and progression of different malignant tumors. As a part of tumor microenvironment, tumor associated macrophages (TAMs) are crucial for the genesis, proliferation, metastasis, and survival of tumor cells. Recently, more and more studies showed that TAMs were related with poor clinical status and survival in patients with diffuse large B cell lymphoma (DLBCL). Considering the complex roles which TAMs play in the tumor microenvironment of DLBCL, the aim of this study was to review the biological mechanisms between TAMs and DLBCL cells, including extracellular matrix remodeling and angiogenesis promotion, tumor promotion, immune suppression, and phagocytosis inhibition. This review will help us to further understand the comprehensive impact of TAMs on DLBCL and explore possible prognostic markers and therapeutic targets.