Thrombomodulin as a marker for vascular tumors. Comparative study with factor VIII and Ulex europaeus I lectin.
Thrombomodulin as a marker for vascular tumors. Comparative study with factor VIII and Ulex europaeus I lectin.
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血栓调节蛋白作为血管肿瘤的标志物。
DOI：
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发表时间：
1987
影响因子：
3.5
通讯作者：
Eiichi Sato
中科院分区：
文献类型：
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作者：
S. Yonezawa;I. Maruyama;K. Sakae;A. Igata;P. Majerus;Eiichi Sato
血栓调节蛋白(TM)是一种新发现的内皮细胞相关蛋白，通过将凝血酶从促凝血酶转化为抗凝血剂而发挥强大的天然抗凝剂的作用。用抗TM多克隆血清对各种血管肿瘤进行免疫过氧化物酶染色。比较TM与血管内皮细胞标志物第八因子相关抗原(FVIII-RAg)和UEA-I(UEA-I)的染色模式。结果表明，与FVIII-RAg或UEA-I相比，TM是血管肉瘤的一种特异和高度敏感的标志物。相反，UEA-I对良性血管肿瘤比TM或FVIII-RAG更敏感。其他非血管起源的间叶性肿瘤三种内皮细胞标志物染色均为阴性。提示TM是诊断血管肉瘤的一种新的、特异、敏感的工具。
Thrombomodulin (TM) is a newly described endothelial cell-associated protein that functions as a potent natural anticoagulant by converting thrombin from a procoagulant protease to an anticoagulant. Various vascular tumors were characterized with immunoperoxidase staining with the use of a polyclonal anti-TM serum. The staining patterns of TM were compared with those of Factor VIII-related antigen (FVIII-RAG) and Ulex europaeus agglutinin-I (UEA-I), which have been used as markers for endothelial cells. The results showed that TM is a specific and a highly sensitive marker for angiosarcomas in comparison with FVIII-RAG or UEA-I. In contrast, UEA-I is more sensitive for benign vascular tumors than TM or FVIII-RAG. The other mesenchymal tumors of nonvascular origin showed negative staining for three endothelial markers. These results indicate that TM is a new specific and sensitive tool for the diagnosis of angiosarcomas.