Circulating preptin levels in normal, impaired glucose tolerance, and type 2 diabetic subjects
Circulating preptin levels in normal, impaired glucose tolerance, and type 2 diabetic subjects
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DOI：
10.1080/07853890802244142
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发表时间：
2009-01-01
影响因子：
4.4
通讯作者：
Li, Ke
中科院分区：
文献类型：
--
作者：
Yang, Gangyi;Li, Ling;Li, Ke
背景Preptin是一种与胰岛素和胰淀素共同分泌的新型激素。Preptin增加葡萄糖介导的胰岛素分泌，而抗preptin抗体结合内源性preptin降低葡萄糖介导的胰岛素分泌。因此，它似乎充当葡萄糖介导的胰岛素分泌的生理放大器。瞄准在这项研究中，我们研究了非糖尿病受试者和糖耐量受损（IGT）或2型糖尿病（T2 DM）患者的血浆preptin水平是否存在差异。法50例T2 DM患者、56例IGT受试者和54例性别和年龄匹配的正常对照参与了研究。用放射免疫法测定血浆preptin水平。还评估了血浆preptin水平与人体测量和代谢参数之间的关系。结果与IGT患者和对照组相比，T2 DM患者的血浆preptin水平更高（分别为45614 vs 41613和39813 ng/L，P0.05和P0.01）。男性血浆preptin水平低于女性（40310 vs 43210 ng/L，P 0.05）。空腹血浆preptin水平与舒张压（DBP）呈正相关（r=0.20，P0.01），甘油三酯（TG）（r=0.24，P0.01），总胆固醇（TC）（r=0.24，P0.01）、高密度脂蛋白胆固醇（HDL-C）（r=0.18，P0.05），游离脂肪酸（FFA）（r=0.21，P0.01），糖负荷后2小时血糖（2 hOGTT）（r=0.18，P0.05），糖化血红蛋白（HbA 1c）（r=0.19，P0.01）和稳态模型评估-胰岛素抵抗指数（HOMAIR）多元逐步回归分析显示，血浆Preptin水平与DBP、TG、HDL-C、FFA独立相关（r=0.13，P0.05）。结论目前的工作表明preptin在T2 DM的发病机制中的潜在作用。
Background. Preptin is a novel hormone that is co-secreted with insulin and amylin from the pancreatic -cells. Preptin increases glucose-mediated insulin secretion, while the binding of endogenous preptin by antipreptin antibodies decreases glucose-mediated insulin secretion. Thus, it appears to act as a physiological amplifier of glucose-mediated insulin secretion. Aim. In this study, we investigate whether plasma preptin levels are different in non-diabetic subjects and patients with impaired glucose tolerance (IGT) or type 2 diabetes mellitus (T2DM). Method. Fifty patients with T2DM, 56 subjects with IGT, and 54 sex- and age-matched normal controls participated in the study. Plasma preptin levels were measured with a radioimmunoassay. The relationships between plasma preptin levels and anthropometric and metabolic parameters were also assessed. Results. Plasma preptin levels were higher in patients with T2DM compared to patients with IGT and controls (45614 versus 41613 and 39813 ng/L, P0.05 and P0.01, respectively). Plasma preptin levels were lower in males than females (40310 versus 43210 ng/L, P0.05). Fasting plasma preptin levels correlated positively with diastolic blood pressure (DBP) (r=0.20, P0.01), triglyceride (TG) (r=0.24, P0.01), total cholesterol (TC) (r=0.24, P0.01), high-density lipoprotein cholesterol (HDL-C) (r=0.18, P0.05), free fatty acids (FFA) (r=0.21, P0.01), 2-h blood glucose after glucose overload (2hOGTT) (r=0.18, P0.05), glycosylated haemoglobin (HbA1c) (r=0.19, P0.01), and homeostasis model assessment-insulin resistance index (HOMAIR) (r=0.13, P0.05) in simple regression analysis of pooled data, while in multiple stepwise regression analysis, only DBP, TG, HDL-C, and FFA were independently related with plasma preptin levels. Conclusion. The present work suggests a potential role of preptin in the pathogenesis of T2DM.