Behavioral/systems/cognitive Functional–anatomic Correlates of Sustained and Transient Processing Components Engaged during Controlled Retrieval
Behavioral/systems/cognitive Functional–anatomic Correlates of Sustained and Transient Processing Components Engaged during Controlled Retrieval
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发表时间：
2003
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通讯作者：
K. Velanova;L. Jacoby;M. Wheeler;M. McAvoy;S. Petersen;R. Buckner
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作者：
K. Velanova;L. Jacoby;M. Wheeler;M. McAvoy;S. Petersen;R. Buckner
控制性加工是情景记忆提取的核心。在本研究中，神经相关的持续，以及短暂的，处理组件进行了探讨，在控制检索使用混合阻塞事件相关的功能磁共振成像范例。来自29名参与者的结果表明，前额叶皮层的某些区域，包括靠近Brodmann区（BA）45/47的左前下额叶皮层和靠近BA 44的左前额叶皮层后部和背部，在提取过程中需要高水平控制时，在逐个试验的基础上增加活动。提供直接证据的控制过程中，参与持续的基础上，右额极皮层强烈相关的持续的时间配置文件在高控制检索条件下，是几个额外的后部区域，包括那些在左顶叶皮层。这些结果为前额叶皮层的功能分离提供了证据。BA 10附近的额极区与时间延长的控制过程，可能是一个注意力集中，或检索模式，在控制检索，而更多的后部前额叶区域与个人检索尝试。特别是，右额极皮层参与持续的过程调和了一些不同的发现时出现的对比块试验范式与事件相关的范式。
Controlled processing is central to episodic memory retrieval. In the present study, neural correlates of sustained, as well as transient, processing components were explored during controlled retrieval using a mixed blocked event-related functional magnetic resonance imaging paradigm. Results from 29 participants suggest that certain regions in prefrontal cortex, including anterior left inferior prefron-tal cortex near Brodmann's Area (BA) 45/47 and more posterior and dorsal left prefrontal cortex near BA 44, increase activity on a trial-by-trial basis when high levels of control are required during retrieval. Providing direct evidence for control processes that participate on an ongoing basis, right frontal-polar cortex was strongly associated with a sustained temporal profile during high control retrieval conditions, as were several additional posterior regions, including those within left parietal cortex. These results provide evidence for functional dissociation within prefrontal cortex. Frontal-polar regions near BA 10 associate with temporally extended control processes that may underlie an attentional set, or retrieval mode, during controlled retrieval, whereas more posterior prefrontal regions associate with individual retrieval attempts. In particular, right frontal-polar cortex involvement in sustained processes reconciles a number of disparate findings that have arisen when contrasting blocked-trial paradigms with event-related paradigms.