Risk of spontaneous abortion in women with childhood exposure to parental cigarette smoke
Risk of spontaneous abortion in women with childhood exposure to parental cigarette smoke
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儿童时期接触过父母吸烟的妇女自然流产的风险
DOI：
10.1093/aje/kwm128
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发表时间：
2007-09-01
影响因子：
5
通讯作者：
Hauser, Russ
中科院分区：
文献类型：
--
作者：
Meeker, John D.;Missmer, Stacey A.;Hauser, Russ
人们越来越关注生命早期的环境暴露是否会影响成年期的健康。最近的证据表明，产前或儿童时期接触香烟烟雾可能导致生命后期生殖健康较差。研究人员从马萨诸塞州波士顿的三家诊所招募了2162名在1994年至2003年期间接受辅助生殖治疗的不吸烟妇女，计算了在最初治疗周期中怀孕结果的调整优势比与自我报告的童年暴露于父母吸烟的关系。与父母均不吸烟的女性相比，父母均吸烟的女性发生自然流产的几率更高（调整后的优势比= 1.8,95%可信区间：1.0,3.0）。研究发现，父母中有一人、一人或两人吸烟的女性患肺癌的风险有增加的趋势。在二次分析中，作者还发现，在报告目前接触二手烟的妇女中，胚胎植入失败的风险增加了。未来需要对流产进行大规模研究，以区分妇女在童年时期和在子宫内接触烟草烟雾的情况。
There is increasing concern over whether environmental exposures early in life may impact health in adulthood. Recent evidence suggests that prenatal or childhood exposure to cigarette smoke may result in poorer reproductive health later in life. Among 2,162 nonsmoking women recruited from three Boston, Massachusetts, clinics who underwent assisted reproductive treatments between 1994 and 2003, adjusted odds ratios for pregnancy outcomes in the initial treatment cycle were calculated in relation to self-reported childhood exposure to parental cigarette smoke. Women who reported having two parents who smoked during their childhood had increased odds of a spontaneous abortion compared with women reporting that neither parent smoked (adjusted odds ratio = 1.8, 95% confidence interval: 1.0, 3.0). A trend for increased risk was observed for women reporting that zero, one, or two parents smoked. In secondary,analysis, the authors also found suggestive evidence for increased risk of failed embryo implantation among women reporting current secondhand tobacco smoke exposure. Future large studies of pregnancy loss are needed that can distinguish women's tobacco smoke exposure in childhood from that taking place in utero.