Liver Function Test by Gadolinium-Ethoxybenzyl-Diethylenetriamine Penta-acetic Acid-Enhanced Magnetic Resonance Imaging with Consideration of Intrahepatic Regional Differences
Liver Function Test by Gadolinium-Ethoxybenzyl-Diethylenetriamine Penta-acetic Acid-Enhanced Magnetic Resonance Imaging with Consideration of Intrahepatic Regional Differences
复制标题
DOI：
10.5754/hge.13291
复制
发表时间：
2013-10-01
影响因子：
--
通讯作者：
Watanabe, Sumio
中科院分区：
文献类型：
--
作者：
Okubo, Hironao;Mogami, Miwa;Watanabe, Sumio
背景/目的：利用Gd-EOBDTPA增强磁共振成像准确定量肝功能。方法：对105例疑似肝脏肿瘤的患者(Child-Pugh评分：56例5分，26例6分，20例7分，3例8分)进行了Gd-EOB-DTPA增强磁共振成像和15min吲哚青绿滞留率(ICG-R15)评估。注射Gd-EOB-DTPA后20min拍摄肝胆图像。通过计算脾和肝内12个点的信号强度来测量定量肝脾对比度(Q-LSC)，这些点包括两个主要肝叶的每个中央区(靠近肝门)和周围区(靠近被膜下区)。结果：无论肝功能如何，中央区或右叶6个点的平均Q-LSC均显著高于外周区或左叶。12分的平均Q-LSC与ICG-R15显著相关，并随着Child-Pugh评分的升高而显著降低。结论：Gd-EOB-DTPA增强扫描的肝脏增强效果受肝带和肝叶差异的影响。这种考虑区域差异的方法对于Gd-EOB-DTPA增强磁共振成像评估肝功能是有效的。
Background/Aims: To accurately quantify liver function using gadolinium-ethoxybenzyl-diethylenetriamine penta-acetic acid (Gd-EOBDTPA)-enhanced MR imaging. Methodology: A total of 105 patients with suspicion of a hepatic tumor (Child-Pugh scores: 5 in 56, 6 in 26, 7 in 20, and 8 in 3) who underwent Gd-EOB-DTPA-enhanced MR imaging and an indocyanine green retention rate at 15 min (ICG-R15) evaluation were retrospectively analyzed. The hepatobiliary images were taken at 20 min after Gd-EOB-DTPA injection. The quantitative liver-spleen contrast ratio (Q-LSC) was measured by calculating the signal intensity of the spleen and 12 intrahepatic points consisting of each central zone (near the porta hepatis) and peripheral zone (near the subcapsular zone) in the two main liver lobes. Results: Each averaged Q-LSC of six points in the central zone or right lobe was significantly higher than that in the peripheral zone or left lobe regardless of hepatic function. The mean Q-LSC of the 12 points was significantly correlated with the ICG-R15 and significantly decreased with elevation of the Child-Pugh score. Conclusions: The hepatic enhancement by Gd-EOB-DTPA is influenced by zonal and lobar differences. This method with consideration of regional differences is valid for estimation of liver function by Gd-EOB-DTPA-enhanced MR imaging.