Evaluation of Antihypertensive and Antihyperlipidemic Effects of Bamboo Shoot Angiotensin Converting Enzyme Inhibitory Peptide in Vivo
Evaluation of Antihypertensive and Antihyperlipidemic Effects of Bamboo Shoot Angiotensin Converting Enzyme Inhibitory Peptide in Vivo
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竹笋血管紧张素转换酶抑制肽体内降压降脂作用评价
DOI：
10.1021/jf303471f
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发表时间：
2012-11-14
影响因子：
6.1
通讯作者：
Zhang, Ying
中科院分区：
文献类型：
--
作者：
Liu, Lianliang;Liu, Lingyi;Zhang, Ying
竹笋血管紧张素对心血管的保护作用。本文研究了竹笋转化酶（ACE）抑制肽（BSP）对自发性高血压大鼠（SHR）的降压作用和对高脂饮食诱导的大鼠的降压作用。观察BSP对自发性高血压大鼠（SHR）30天的降压作用。ASP. Tyr [10 mg/天/kg体重（BW）]和BSP（50 mg/天/kg BW）在相同水平上显著降低肺中的ACE活性（p < 0.05），而BSP（50 mg/天/kg BW）更有效地降低收缩压（SBP），其酚类化合物如阿魏酸和p-香豆酸。与ACE抑制剂合用，BSP能显著降低收缩压，改善氧化应激状态（GSH-Px、SOD、TAC和MDA），提高血清NO水平和肾脏NOS活性。BSP降低总胆固醇。(TC)结论：Asp Tyr对高脂血症大鼠的ACE抑制作用和酚类化合物对脂肪酸合成酶的抑制作用可能与其降低高脂血症大鼠的甘油三酯（TG）、低密度脂蛋白胆固醇（LDL-c）和丙二醛（MDA）水平有关。
Cardiovascular protective functions of bamboo shoot angiotensin. Converting enzyme (ACE) inhibitory :peptide (BSP) from bamboo shoot Were evaluated, including antihypertensive effect on spontaneously hypertensive rats (SHRs) an antihyperlipidemic effect on :high-fat-diet-induced rats. Thirty day antihypertensive effects of BSP on SHRs were assayed. Asp. Tyr [10 mg/day kg body weight (BW)] and BSP (50 mg/day kg BW) significantly reduced ACE activity in lung at the same level (p < 0.05), while BSP (50 mg/day kg BW) reduced systolic blood pressure (SBP) more effectively for its phenolic compounds, such as ferulic acid and p-coumaric. acid, which when combined with ACE inhibitor exert a synergistic effect BSP could significantly reduce SBP, improve oxidant stress Status (GSH-Px, SOD, TAC and MDA), and increase NO level in serum and NOS activity in kidney. BSP decreased total cholesterol.(TC), triglyceride (TG), and low density lipoprotein cholesterol (LDL-c) content and MDA level of hyperlipidemic rats, which might contribute to the ACE inhibitory capacity of Asp Tyr and the fatty acid synthase inhibitory activity of phenolic compounds.