Risk factors of gastric cancer specific for tumor location and histology in Cali, Colombia
Risk factors of gastric cancer specific for tumor location and histology in Cali, Colombia
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DOI：
10.3748/wjg.v12.i36.5772
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发表时间：
2006-09-28
影响因子：
4.3
通讯作者：
Akiba, Suminori
中科院分区：
文献类型：
--
作者：
Campos, Francia;Carrasquilla, Gabriel;Akiba, Suminori
目的：探讨胃癌（GC）的组织学和肿瘤部位特异性危险因素。方法：本研究为病例对照研究。研究对象为2000-2002年期间新诊断的216例胃癌患者和431例对照，这些对照从年龄、性别和医院相匹配的非癌症患者中选择。我们通过问卷调查获得了他们的生活方式、饮食习惯和其他方面的信息。结果：在他/她的兄弟姐妹中年龄不是最大的受试者有轻微升高的GC风险（OR 1.3; 95% CI 0.8-2.0）。盐腌制食物。品尝前饮用与GC风险增加相关（OR 3.5; 95% CI 1.6-7.3）。经常食用水果（OR 0.3; 95% CI 0.1-1.0）和蔬菜（OR 0.3; 95% CI 0.1-1.0）与降低胃癌风险相关。另一方面，油炸食品（OR 1.9; 95% CI 1.0-3.6）和用煤做饭（OR 1.8; 95% CI 1.3-2.6）与胃癌风险增加有关。除了出生顺序外，Lauren的组织学分类（肠型和弥漫性）和肿瘤位置都没有显著影响这些关联。在他/她的兄弟姐妹中年龄不是最大的受试者在远端和中三分之一处发生GCs的风险增加，其or分别为1.7 （95% CI 1.0-2.8）和1.9 （95% CI 0.8-4.3）。上三分之一胃相应的OR为0.3 （95% CI 0.1-0.9）。三个or的差异有统计学意义（P = 0.010）。结论：本研究表明，出生顺序、盐摄入量、水果和蔬菜的摄入量、烹饪方式和吸烟与胃癌风险有关。在组织学和肿瘤位置特异性分析中，兄弟姐妹中年龄较小的人与胃远端和中部三分之一的胃癌风险增加有关，与心脏胃癌风险降低有关。(C) 2006 WJG出版社。版权所有。
AIM: To examine histology- and tumor-location specific risk factors of gastric cancer (GC).METHODS: This was a case-control study. The study subjects were 216 GC patients newly diagnosed during the period 2000-2002 and 431 controls selected from non-cancer patients matching in age, gender, and hospital. We obtained information on lifestyles, dietary habits, and others by a questionnaire.RESULTS: The subjects who were not eldest among his/her siblings were at a slightly elevated GC risk (OR 1.3; 95% CI 0.8-2.0). Salting meals. before tasting was related to an increased GC risk (OR 3.5; 95% CI 1.6-7.3). Frequent consumptions of fruits (OR 0.3; 95% CI 0.1-1.0) and vegetables (OR 0.3; 95% CI 0.1-1.0) were related to decreased GC risks. On the other hand, frying foods (OR 1.9; 95% CI 1.0-3.6) and cooking with coal (OR 1.8; 95% CI 1.3-2.6) were related to increased GC risks. Neither Lauren's histological classification (intestinal and diffuse types) nor tumor location significantly affected those associations except birth order. The subjects who were not eldest among his/her siblings had an increased risk of GCs in the distal and middle thirds, and their ORs were 1.7 (95% CI 1.0-2.8) and 1.9 (95% CI 0.8-4.3), respectively. The corresponding OR in the upper third stomach was 0.3 (95% CI 0.1-0.9). The differences of those three ORs were statistically significant (P = 0.010).CONCLUSION: The present study shows that birth order, salt intake, consumption of fruits and vegetables, the type of cooking, and cigarette smoking are related to GC risk. In histology and tumor-location specific analyses, non-eldest person among their siblings is related to an increased GC risk in the distal and middle thirds of the stomach, and is related to a decreased GC risk in the cardia. (C) 2006 The WJG Press. All rights reserved.