Oxyprenylated Phenylpropanoids Bind to MT1 Melatonin Receptors and Inhibit Breast Cancer Cell Proliferation and Migration
Oxyprenylated Phenylpropanoids Bind to MT1 Melatonin Receptors and Inhibit Breast Cancer Cell Proliferation and Migration
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DOI：
10.1021/acs.jnatprod.7b00853
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发表时间：
2017-12-01
影响因子：
5.1
通讯作者：
Witt-Enderby, Paula A.
中科院分区：
文献类型：
--
作者：
Hasan, Mahmud;Genovese, Salvatore;Witt-Enderby, Paula A.
氧代异戊二烯化的化合物（即，阿魏酸和香豆素衍生物）显示出神经保护和抗癌特性，如先前研究中所报道的。我们已经测试了氧异戊二烯化的阿魏酸（1-4）和伞形酮衍生物（5-11）对褪黑激素受体的亲和力以及它们对乳腺癌（BC）细胞系的抗增殖和抗迁移特性。除了阿魏酸、硼丙酸和伞形酮之外的所有化合物对褪黑激素受体的结合亲和力在nM至μ M范围内，并且在包括三阴性在内的表型多样性BC中，auraptene和umbellinprenin都降低了BC细胞增殖和迁移。
Oxyprenylated compounds (i.e., ferulic acid and coumarin derivatives) demonstrate neuroprotection and anticancer properties as reported in previous studies. We have tested the affinity of oxyprenylated ferulic acid (1-4) and umbelliferone derivatives (5-11) to melatonin receptors as well as their antiproliferation and antimigratory properties against breast cancer (BC) cell lines. All the compounds except for ferulic acid, boropinic acid, and umbelliferone had binding affinities to melatonin receptors in the nM to mu M range, and both auraptene and umbellinprenin reduced BC cell proliferation and migration in phenotypically diverse BC including triple negative.