Variations in the number of uterine angiotensin receptors following changes in plasma angiotensin levels.
Variations in the number of uterine angiotensin receptors following changes in plasma angiotensin levels.
复制标题
血浆血管紧张素水平变化后子宫血管紧张素受体数量的变化。
DOI：
10.1016/0014-2999(76)90350-2
复制
发表时间：
1976
影响因子：
5
通讯作者：
P. Meyer
中科院分区：
文献类型：
--
作者：
M. Devynck;B. Rouzaire‐Dubois;E. Chevillotte;P. Meyer
3 H-标记的血管紧张素II结合受体网站进行了研究，从子宫角肌层匀浆分离的质膜。去除肾脏，这导致血浆血管紧张素II的消失，随后19小时肾切除术后子宫受体位点的数量增加，而没有显着变化的表观解离常数。急性加压静脉注射血管紧张素II肾切除大鼠切除子宫前，并没有影响子宫血管紧张素受体的数量，而长期的血管紧张素输注确实减少受体的数量。这些变化不能用受体位点占有率的变化来解释。这些结果表明，血管紧张素受体的数量，至少在子宫收缩细胞，是受内源性血管紧张素水平的慢性变化。本文讨论了肾切除大鼠子宫对血管紧张素II的特异性超敏感性与受体水平变化之间的关系。
3H-labelled angiotensin II binding to receptor sites was studied in plasma membranes isolated from myometrial homogenates of uterine horns. Removal of the kidneys, which results in the disappearance of plasma angiotensin II, was followed 19 h after nephrectomy by an increase in the number of uterine receptor sites without significant variation in the apparent dissociation constant. Acute pressor i.v. injection of angiotensin II into nephrectomized rats immediately before removing uteri, did not affect the number of uterine angiotensin receptors, whereas long-lasting angiotensin infusion did reduce the number of receptors. These changes cannot be accounted for by variations in the occupancy of receptor sites. These results demonstrate that the number of angiotensin receptors, at least in uterine contractile cells, is affected by chronic variations of endogenous angiotensin levels. The relation between the specific supersensitivity to angiotensin II observed in uteri from nephrectomized rats and the variations at the receptor level is discussed.