A retrospective analysis of the effect of contrast-enhanced CT on the outcome of acute pancreatitis.
A retrospective analysis of the effect of contrast-enhanced CT on the outcome of acute pancreatitis.
复制标题
增强CT对急性胰腺炎预后影响的回顾性分析
DOI：
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发表时间：
1996
影响因子：
9.8
通讯作者：
Gates Lk
中科院分区：
文献类型：
--
作者：
M. Da;Gates Lk
目标
CT增强扫描被广泛用于评估急性胰腺炎的严重程度。最近，在大鼠中进行的研究表明，静脉注射造影剂可改善实验性急性胰腺炎的结局。本研究的目的是确定静脉注射造影剂对临床急性胰腺炎的影响。
方法
回顾了1992年以来肯塔基州大学医院的急性胰腺炎ICD-9编码的病历。计算所有患者诊断胰腺炎时的APACHE II评分。临床胰腺炎的持续时间确定为从疼痛发作之日至疼痛消退和恢复口服营养之日。使用Mann-Whitney秩和检验比较对比CT和非对比组。
结果
两组患者的APACHE II评分差异无统计学意义。对比CT组的临床胰腺炎平均持续时间为10.8天，而非CT组为6.2天（p = 0.004）。
结论
这项回顾性研究支持最近动物研究的结论，即静脉注射造影剂可能加重或延长急性胰腺炎的发作。
OBJECTIVES
Contrast CT is widely used to assess the severity of acute pancreatitis. Recently, studies in rats have shown that the administration of i.v. contrast material worsens the outcome of experimental acute pancreatitis. The aim of the current study was to determine if an effect of the administration of i.v. contrast could be identified in clinical acute pancreatitis.
METHODS
Charts from the University of Kentucky Hospital from 1992 with an ICD-9 code of acute pancreatitis were reviewed. APACHE II scores at diagnosis of pancreatitis were calculated for all patients. The duration of clinical pancreatitis was determined from the date of onset of pain to the date of resolution of pain and resumption of oral nutrition. Contrast CT and noncontrast groups were compared using a Mann-Whitney rank sum test.
RESULTS
There was no significant difference in the original APACHE II scores between the two groups. The contrast CT group had a mean duration of clinical pancreatitis of 10.8 days versus 6.2 days for the non-CT group (p = 0.004).
CONCLUSIONS
This retrospective study supports the conclusions of recent animal studies that suggest that i.v. contrast might worsen or prolong attacks of acute pancreatitis.