The PaO(2)/FiO(2) is independently associated with 28-day mortality in patients with sepsis: a retrospective analysis from MIMIC-IV database.
The PaO(2)/FiO(2) is independently associated with 28-day mortality in patients with sepsis: a retrospective analysis from MIMIC-IV database.
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DOI：
10.1186/s12890-023-02491-8
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发表时间：
2023-05-27
影响因子：
3.1
通讯作者：
中科院分区：
文献类型：
--
作者：
To clarify the relationship between the PaO2/FiO2 and 28-day mortality in patients with sepsis. This was a retrospective cohort study regarding MIMIC-IV database. Nineteen thousand two hundred thirty-three patients with sepsis were included in the final analysis. PaO2/FiO2 was exposure variable, 28-day mortality was outcome variable. PaO2/FiO2 was log-transformed as LnPaO2/FiO2. Binary logistic regression was used to explore the independent effects of LnPaO2/FiO2 on 28-day mortality using non-adjusted and multivariate-adjusted models. A generalized additive model (GAM) and smoothed curve fitting was used to investigate the non-linear relationship between LnPaO2/FiO2 and 28-day mortality. A two-piecewise linear model was used to calculate the OR and 95% CI on either side of the inflection point. The relationship between LnPaO2/FiO2 and risk of 28-day death in sepsis patients was U-shape. The inflection point of LnPaO2/FiO2 was 5.30 (95%CI: 5.21—5.39), which indicated the inflection point of PaO2/FiO2 was 200.33 mmHg (95%CI: 183.09 mmHg—219.20 mmHg). On the left of inflection point, LnPaO2/FiO2 was negatively correlated with 28-day mortality (OR: 0.37, 95%CI: 0.32—0.43, p < 0.0001). On the right of inflection point, LnPaO2/FiO2 was positively correlated with 28-day mortality in patients with sepsis (OR: 1.53, 95%CI: 1.31—1.80, p < 0.0001). In patients with sepsis, either a high or low PaO2/FiO2 was associated with an increased risk of 28-day mortality. In the range of 183.09 mmHg to 219.20 mmHg, PaO2/FiO2 was associated with a lower risk of 28-day death in patients with sepsis.
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影响因子：
2.2
作者：
Vincent JL;Taccone FS;He X
通讯作者：
He X
血细胞比容与败血症患者 30 天死亡率之间的关系： 基于大型临床数据库 MIMIC-IV 的回顾性分析。
影响因子：
3.7
作者：
Luo M;Chen Y;Cheng Y;Li N;Qing H
通讯作者：
Qing H
DOI：
10.1177/03000605211004759
发表时间：
2021-04
期刊：
The Journal of international medical research
影响因子：
--
作者：
Zhang M;Duan M;Zhi D;Lin J;Liu P;Wang Y
通讯作者：
Wang Y
影响因子：
--
作者：
Cao B;Chen Q;Tang T;Li H;Zhong X;Hao P;He Q;Chen Y
通讯作者：
Chen Y
DOI：
10.1136/bmj.k3532
发表时间：
2018-11-14
期刊：
BMJ (Clinical research ed.)
影响因子：
--
作者：
Langan SM;Schmidt SA;Wing K;Ehrenstein V;Nicholls SG;Filion KB;Klungel O;Petersen I;Sorensen HT;Dixon WG;Guttmann A;Harron K;Hemkens LG;Moher D;Schneeweiss S;Smeeth L;Sturkenboom M;von Elm E;Wang SV;Benchimol EI
通讯作者：
Benchimol EI