Comparison of the response to histamine challenge of the nose and the maxillary sinus: effect of loratadine
Comparison of the response to histamine challenge of the nose and the maxillary sinus: effect of loratadine
复制标题
DOI：
10.1152/jappl.1999.87.3.1038
复制
发表时间：
1999-09-01
影响因子：
3.3
通讯作者：
Naclerio, RM
中科院分区：
文献类型：
--
作者：
Baroody, FM;Gungor, A;Naclerio, RM
为了研究上颌窦对组胺激发的反应，我们进行了一项双盲、随机、交叉试验，在此期间，无鼻炎症状的非过敏受试者（n = 25）接受10 mg氯雷他定或安慰剂，每日一次，持续一周，然后接受组胺鼻腔激发（3，10，和30毫克/毫升），随后，24小时后，上颌窦挑战，同时仍接受药物。组胺鼻腔激发导致血管通透性、反射性鼻分泌物、打喷嚏和其他鼻部症状显著增加。窦腔刺激后，窦腔内血管通透性明显增加（P < 0.01），并出现一些鼻部症状，但鼻分泌物反射性无明显变化。窦粘膜对组胺的反应幅度低于鼻粘膜。氯雷他定治疗可显著抑制组胺引起的鼻腔和鼻窦变化。我们的数据表明，缺乏鼻窦反射反应组胺激发非过敏性个体的上颌窦。
To study the response of the maxillary sinus to histamine provocation, we performed a double-blind, randomized, crossover trial during which nonallergic subjects without symptoms of rhinitis (n = 25) received either 10 mg loratadine or placebo once daily for a week and then underwent nasal challenge with histamine (3, 10, and 30 mg/ml) followed, 24 h later, by a maxillary sinus challenge while still receiving the medication. Nasal challenge with histamine led to significant increases in vascular permeability, reflex nasal secretions, sneezing, and other nasal symptoms. Sinus challenge resulted in significant increases in vascular permeability within the sinus cavity (P < 0.01) and some nasal symptoms but no significant change in reflex nasal secretions. The response of the sinus mucosa to histamine was lower in magnitude than that of the nose. Treatment with loratadine resulted in a significant inhibition of the histamine-induced changes in both nasal and sinus cavities. Our data suggest the lack of a sinonasal reflex response to histamine provocation of the maxillary sinus of nonallergic individuals.