Endothelial dysfunction in the apolipoprotein E-deficient mouse: insights into the influence of diet, gender and aging.
Endothelial dysfunction in the apolipoprotein E-deficient mouse: insights into the influence of diet, gender and aging.
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DOI：
10.1186/1476-511x-10-211
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发表时间：
2011-11-14
影响因子：
4.5
通讯作者：
Vasquez EC
中科院分区：
文献类型：
--
作者：
Meyrelles SS;Peotta VA;Pereira TM;Vasquez EC
自 20 世纪 90 年代初以来，几种转基因小鼠已被开发为实验性动脉粥样硬化模型。在可用的模型中，载脂蛋白 E 缺陷 (apoE-/-) 小鼠尤其具有相关性，因为它倾向于自发发生高胆固醇血症和动脉粥样硬化病变，与人类中发现的相似，即使小鼠被喂食饲料也是如此。本综述的主要目的是强调有助于阐明 apoE-/- 小鼠血管功能障碍机制的关键成就。首先，我们总结了 apoE-/- 小鼠的脂蛋白和动脉粥样硬化表型，然后我们简要讨论了有关性别对该小鼠模型中动脉粥样硬化发展的影响的有争议的证据。其次，我们讨论了传导血管和阻力血管内皮功能障碍的主要机制，并研究了 apoE-/- 小鼠的饮食、衰老和性别如何影响这种血管缺陷。
Since the early 1990s, several strains of genetically modified mice have been developed as models for experimental atherosclerosis. Among the available models, the apolipoprotein E-deficient (apoE-/-) mouse is of particular relevance because of its propensity to spontaneously develop hypercholesterolemia and atherosclerotic lesions that are similar to those found in humans, even when the mice are fed a chow diet. The main purpose of this review is to highlight the key achievements that have contributed to elucidating the mechanisms pertaining to vascular dysfunction in the apoE-/- mouse. First, we summarize lipoproteins and atherosclerosis phenotypes in the apoE-/- mouse, and then we briefly discuss controversial evidence relative to the influence of gender on the development of atherosclerosis in this murine model. Second, we discuss the main mechanisms underlying the endothelial dysfunction of conducting vessels and resistance vessels and examine how this vascular defect can be influenced by diet, aging and gender in the apoE-/- mouse.