Multiple functions of USP18.
Multiple functions of USP18.
复制标题
USP18的多个功能。
DOI：
10.1038/cddis.2016.326
复制
发表时间：
2016-11-03
影响因子：
9
通讯作者：
Lang KS
中科院分区：
文献类型：
--
作者：
Honke N;Shaabani N;Zhang DE;Hardt C;Lang KS
自从泛素系统被发现并描述其在蛋白质降解中的重要作用以来，许多研究表明了泛素特异性肽酶（USP）的重要性。这个家族的一个特殊成员是USP18蛋白（以前称为UBP 43）。在过去的二十年中，USP18的几种功能已经被发现：该蛋白不仅是一种异肽酶，而且是干扰素信号传导的有效抑制剂。因此，USP18在各种细胞类型中充当许多生物学途径的“大师”。本文综述了USP18在调节各种免疫过程中的多种功能，包括病原体控制，癌症发展和自身免疫性疾病。
Since the discovery of the ubiquitin system and the description of its important role in the degradation of proteins, many studies have shown the importance of ubiquitin-specific peptidases (USPs). One special member of this family is the USP18 protein (formerly UBP43). In the past two decades, several functions of USP18 have been discovered: this protein is not only an isopeptidase but also a potent inhibitor of interferon signaling. Therefore, USP18 functions as 'a' maestro of many biological pathways in various cell types. This review outlines multiple functions of USP18 in the regulation of various immunological processes, including pathogen control, cancer development, and autoimmune diseases.