Histoplathology and regression of retinal hard exudates in diabetic retinopathy after reduction of elevated serum lipid levels
Histoplathology and regression of retinal hard exudates in diabetic retinopathy after reduction of elevated serum lipid levels
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DOI：
10.1016/j.ophtha.2003.01.001
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发表时间：
2003-11-01
期刊：
影响因子：
13.7
通讯作者：
Ferris, FL III
中科院分区：
文献类型：
--
作者：
Cusick, M;Chew, EY;Ferris, FL III
目的：描述2例糖尿病性黄斑病变患者视网膜硬性渗出物的消退，并报告反映视网膜脂质沉积的免疫组织学结果。设计：两个干预性病例报告。方法：两名渗出性糖尿病性黄斑病变患者进行治疗，使血脂正常化。组织学检查和免疫组化每个病人的眼睛进行评估的本地化载脂蛋白B和胆固醇酯，这两者都是低密度lipoprotein.Results的主要成分：这两个病人表现出显着的回归后，纠正血脂异常的视网膜硬性渗出物。组织病理学显示视网膜中弥漫性脂质和胆固醇酯。载脂蛋白B和巨噬细胞共定位于血管周围空间。结论：硬渗出物的消退最有可能是由于在这两个病人积极的降脂。硬性渗出物和糖尿病性黄斑病变的新组织病理学发现与在较大动脉粥样硬化病变中观察到的病理学变化相似，除了它们发生在视网膜内血管周围间隙。(C)2003年，美国眼科学会。
Purpose: To describe a regression of retinal hard exudates in 2 patients with diabetic maculopathy, and to report immunohistologic findings reflecting lipid deposition in the retina.Design: Two interventional case reports.Methods: Two patients with exudative diabetic maculopathy were treated to normalize serum lipids. Histologic examination and immunohistochemistry of each patient's eyes were performed to assess the localization of apolipoprotein B and cholesteryl ester, both of which are principal components of low-density lipoprotein.Results: Both patients showed a dramatic regression of retinal hard exudates after correction of dyslipidemia. Histopathology revealed diffuse lipids and cholesteryl ester in the retina. Apolipoprotein B and macrophages were colocalized in the perivascular space.Conclusions: The regression of hard exudates was most likely due to the aggressive lipid lowering in both patients. The novel histopathologic findings of hard exudate and diabetic maculopathy are similar to the pathologic changes observed in larger atherosclerotic lesions, except that they occur in the intraretinal perivascular space. (C) 2003 by the American Academy of Ophthalmology.