PERMEABILITY OF THE HUMAN PLACENTA INVIVO TO 4 NON-METABOLIZED HYDROPHILIC MOLECULES
PERMEABILITY OF THE HUMAN PLACENTA INVIVO TO 4 NON-METABOLIZED HYDROPHILIC MOLECULES
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DOI：
10.1113/jphysiol.1990.sp018343
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发表时间：
1990-12-01
影响因子：
5.5
通讯作者：
STACEY, TE
中科院分区：
文献类型：
--
作者：
BAIN, MD;COPAS, DK;STACEY, TE
在7例正常足月妊娠的剖宫产术中，测量了人胎盘对四种不同分子大小的渗透剂的渗透性。胎盘对甘露醇的清除量为8.7±-。1.1毫升分钟-1(平均+-。S.E.M.)，乳果糖6.3+-。0.8，乙二胺四乙酸(CrEDTA)3.7.+-。0.5，菊粉0.98.+-。0.1。渗透率数据被分析的条件下，限制扩散通过‘’名义‘’充满水的孔隙，发现不符合单一群体的统一孔隙。
Permeability of the human placenta to four permeants of different molecular size was measured at Caesarean section in seven normal full-term pregnancies. Placental clearance for mannitol was 8.7 .+-. 1.1 ml min-1 (mean .+-. S.E.M.), lactulose 6.3 .+-. 0.8, chromium ethylenediaminetetraacetic acid (CrEDTA) 3.7 .+-. 0.5, and inulin 0.98 .+-. 0.1. The permeability data were analysed in terms of restricted diffusion through ''notional'' water-filled pores and found to be incompatible with a single population of uniform pores.