The role of general intelligence as an intermediate phenotype for neuropsychiatric disorders.
The role of general intelligence as an intermediate phenotype for neuropsychiatric disorders.
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DOI：
10.1080/13546800902805347
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发表时间：
2009-01-01
影响因子：
1.7
通讯作者：
Malhotra, Anil K
中科院分区：
文献类型：
--
作者：
Burdick, Katherine E;Gunawardane, Nisali;Malhotra, Anil K
引言：神经认知障碍是常见的几种神经精神疾病。在精神病学中，越来越多地使用认知障碍作为一种中间表型或“内表型”，这就提出了一个问题，即在分子遗传学研究中，认知的整体测量（如智商）或更具体的认知领域（如工作记忆）的测定是否能最好地提高检测易感基因座的能力。本文将回顾精神分裂症和双相情感障碍的一般智力研究，并评价其作为候选中间表型的优势和不足。虽然整体认知测量可能不是双相情感障碍的最佳中间表型，但精神分裂症和双相情感障碍之间重叠的某些临床特征，如精神病，可能预测整体测量的表现不佳，无论DSM-IV分类如何。认知的整体测量代表精神分裂症的良好中间表型。目前的研究不支持使用整体认知测量作为双相情感障碍的中间表型。特定神经认知领域的检测可能具有更大的潜力来检测双相情感障碍的遗传标记。
INTRODUCTION: Neurocognitive impairment is common to several neuropsychiatric disorders. The growing use of cognitive impairment as an intermediate phenotype, or "endophenotype", in psychiatry raises the issue of whether global measures of cognition, such as IQ, or assays of more specific cognitive domains, such as working memory, will best serve to enhance power in detecting susceptibility loci in molecular genetic studies.METHODS: This paper will review the research on general intelligence in schizophrenia and bipolar disorder and evaluate its strengths and weaknesses as a candidate intermediate phenotype.RESULTS: Although global measures of cognition may not be optimal as intermediate phenotypes in bipolar disorder, certain clinical traits that overlap between schizophrenia and bipolar disorder, such as psychosis, may be predictive of poor performance on global measures, regardless of DSM-IV categorisation.CONCLUSIONS: Global measures of cognition represent good intermediate phenotypes in schizophrenia. Current research does not support the use of global measures of cognition as intermediate phenotypes for bipolar disorder. Assays of specific neurocognitive domains may have greater potential to detect genetic markers for bipolar disorder.