High-frequency rTMS with two different inter-train intervals improves upper limb motor function at the early stage of stroke
High-frequency rTMS with two different inter-train intervals improves upper limb motor function at the early stage of stroke
复制标题
具有两种不同训练间隔的高频rTMS改善中风早期的上肢运动功能
DOI：
10.1177/0300060520928737
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发表时间：
2020-06-12
期刊：
影响因子：
--
通讯作者：
Zhou X
中科院分区：
文献类型：
--
作者：
Ke J;Zou X;Huang M;Huang Q;Li H;Zhou X
目的探讨两种不同训练间隔的高频重复经颅磁刺激（HF-rTMS）对脑卒中早期上肢运动功能的治疗效果。方法选取48例脑卒中后早期患者，随机分为假手术组、ITI短（8 s）组和ITI长（28 s）组。HF-rTMS以20 Hz的频率传递。在受影响的皮层区域，运动诱发电位的振幅，代表拇短外展肌，反映皮层的兴奋性。在基线，治疗后立即和治疗后1个月，我们使用Brunnstrom恢复分期（BRSs）和Fugl-Meyer上肢功能评估（FMA-UE）评估上肢运动功能的恢复情况，并使用Barthel指数（BI）评估功能独立性。结果与假手术组相比，两种不同ITI的HF-rTMS可显著改善上肢功能恢复，但不同ITI组之间皮质兴奋性变化或BRS、FMA-UE、BI评分无显著差异。结论在脑卒中后早期，短炎症期的HF-rTMS与长炎症期的HF-rTMS的治疗效果相似，提示可以缩短治疗时间。
Objective This study aimed to explore the therapeutic effect of high-frequency repetitive transcranial magnetic stimulation (HF-rTMS) with two different inter-train intervals (ITIs) on upper limb motor function in the early period of stroke. Methods We recruited 48 post-stroke patients in the early period and randomly divided them into three cohorts: the sham group, the short ITI (8 s) group, and the long ITI (28 s) group. HF-rTMS was delivered at 20 Hz. The amplitude of motor evoked potentials at the affected cortical region, representing the abductor pollicis brevis muscle, reflected cortical excitability. At baseline, immediately after treatment, and 1 month after treatment, we evaluated the recovery of upper limb motor function using Brunnstrom recovery stages (BRSs) and the Fugl–Meyer Assessment for upper extremity (FMA-UE), and assessed functional independence using the Barthel Index (BI). Results HF-rTMS with two different ITIs significantly improved upper limb functional recovery relative to the sham group, but there was no significant difference in cortical excitability changes or BRS, FMA-UE, or BI scores between the different ITI groups. Conclusions At the early post-stroke stage, HF-rTMS with short ITIs generates a similar therapeutic effect to HF-rTMS with long ITIs, suggesting that treatment times can be decreased.
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DOI：
10.1016/j.clinph.2009.08.016
发表时间：
2009-12
期刊：
Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology
影响因子：
--
作者：
Rossi S;Hallett M;Rossini PM;Pascual-Leone A;Safety of TMS Consensus Group
通讯作者：
Safety of TMS Consensus Group
影响因子：
8.3
作者：
Hsu, Wan-Yu;Cheng, Chia-Hsiung;Lin, Yung-Yang
通讯作者：
Lin, Yung-Yang
DOI：
10.1016/s0924-980x(97)00036-2
发表时间：
1997-12-01
期刊：
ELECTROMYOGRAPHY AND MOTOR CONTROL-ELECTROENCEPHALOGRAPHY AND CLINICAL NEUROPHYSIOLOGY
影响因子：
--
作者：
Chen, R;Gerloff, C;Cohen, LG
通讯作者：
Cohen, LG
影响因子：
4.7
作者：
Adeyemo BO;Simis M;Macea DD;Fregni F
通讯作者：
Fregni F
每天两次的疗效与每天一次重复的经颅磁刺激治疗中的疗效：一项回顾性研究。
影响因子：
3.2
作者：
Modirrousta M;Meek BP;Wikstrom SL
通讯作者：
Wikstrom SL