Trabecular bone volume and microdamage accumulation in the femoral heads of women with and without femoral neck fractures
Trabecular bone volume and microdamage accumulation in the femoral heads of women with and without femoral neck fractures
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DOI：
10.1016/s8756-3282(97)00200-7
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发表时间：
1997-12-01
期刊：
影响因子：
4.1
通讯作者：
Burr, DB
中科院分区：
文献类型：
--
作者：
Mori, S;Harruff, R;Burr, DB
重复借出会导致骨骼脆弱和微损伤累积，但尚不清楚微裂纹是否会随着人体骨骼年龄的增长而累积，或者股骨颈骨折的老年女性是否比未骨折的老年女性有更多的微损伤。本研究测试了以下假设：（ii 微裂纹随着年龄的增长而在股骨头中积累；（2）患有股骨颈骨折的老年女性比没有骨折的同龄女性具有更多的微裂纹。来自 9 名年轻（16-66 岁）和 12 名老年（73-88 齿轮）女性尸体和 7 名股骨颈骨折女性（56-90 岁）的非骨关节炎股骨头被解剖后，中额板用 1% 碱性品红进行块染色，仅通过组织形态计量学测量 150 微米厚的标本，与年轻受试者相比，老年和骨折受试者中的骨小梁面积百分比显着降低（p 小于或等于 0.05）。与 70 岁以下的受试者相比，70 岁以上的预兆中的微裂纹密度（Cr.Dn）显着更高（p =）。 0.005；Spearman's r = 0.41，p = 0.032），但在有骨折和无骨折的老年女性之间没有差异，与年轻受试者相比，老年和骨折受试者的骨细胞腔隙密度（Ot.Dn）显着较低（p小于或等于0.01），并且与裂纹密度呈负相关（r = -0.49，p = 0.011），Cr.Dn在老年和骨折受试者中较高。 Tb.Ar 较低的女性（Spearman 的 r = -0.56；p = 0.004），并且与 Ot.Dn 成反比（Spearman 的 r = -0.47；p 0.014），这与骨密度低的女性中裂纹累积更快的观点一致。这也与骨细胞网络检测微裂纹及其修复信号的观点一致。 1997 年，Elsevier Science Inc. 保留所有权利。
Repetitive lending causes fragility and microdamage accumulation in the skeleton, but it is not clear whether microcracks accumulate with age in the human skeleton, or whether older women with femoral neck fractures have more microdamage than older women without fracture. This study tested the hypotheses that: (ii microcracks accumulate in the femoral head with age; and (2) older women with femoral neck fractures have significantly more microcracks than similar aged women without fractures. Nonosteoarthritic femoral heads from 9 young (16-66 years) and 12 old (73-88 gears) female cadavers and those from 7 females with femoral neck fractures (56-90 years) were dissected, Midfrontal slabs were block stained with 1% basic fuchsin and 150-mu m-thick specimens mere measured histomorphometrically. Percent trabecular bone area (Tb,Ar significantly decreased in older and fractured subjects compared with young subjects (p less than or equal to 0.05). Microcrack density (Cr.Dn) was significantly higher in a omen older than 70 years compared with those younger than 70 (p = 0.005; Spearman's r = 0.41, p = 0.032), but was not different between older women with and without fractures, Osteocyte lacunar density (Ot.Dn) was significantly less in old and fractured subjects compared with young subjects (p less than or equal to 0.01), and inversely correlated to crack density (r = -0.49, p = 0.011), Cr.Dn was higher in women with low Tb.Ar (Spearman's r = -0.56; p = 0.004), and varied inversely with Ot.Dn (Spearman's r = -0.47; p 0.014). This is consistent with the idea that cracks accumulate more rapidly in women with low bone density. It is also consistent with the idea that the osteocyte network detects microcracks, and signals for their repair. (C) 1997 by Elsevier Science Inc. All rights reserved.