A hypothesis on the development of acute myocardial infarction in Greenlanders.
A hypothesis on the development of acute myocardial infarction in Greenlanders.
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关于格陵兰人急性心肌梗塞发展的假设。
DOI：
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发表时间：
1982
期刊：
影响因子：
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通讯作者：
H. Bang
中科院分区：
文献类型：
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作者：
J. Dyerberg;H. Bang
与西方国家经年龄和性别调整的缺血性心脏病死亡率相比，非移民格陵兰人的急性心肌梗死(AMI)发病率较低。我们发现格陵兰人的血脂水平与急性心肌梗死的有利危险因素水平相对应。这可以归因于他们的饮食，富含n-3多不饱和脂肪。这种饮食进一步补充二十碳五烯酸，二十碳五烯酸在抗血栓方面影响血小板血管壁功能。高水平的血浆抗凝血酶-III，提高血液的抗凝活性，再加上补体系统遗传上较高的激活阈值，可能进一步有助于对血栓栓塞性疾病的抵抗。出血倾向和对感染障碍的易感性可能是可能的回落。我们的数据被纳入一个假设，该假设结合了遗传易感性的迹象和外源性保护因素的证据，造成了对血管缺血性灾难的不敏感性的一致增强。
Non-emigrated Greenlanders have a low incidence of acute myocardial infarction (AMI), when compared with age- and sex adjusted death rates for ischemic heart disease in western countries. We find that Greenlanders have plasma lipid levels corresponding to favourable risk factor levels for AMI. This can be attributed to their diet, rich in n-3 polyunsaturated fat. This diet further supplies eicosapentaenoic acid which influence platelet vessel wall function in an antithrombotic direction. A high level of plasma-antithrombin-III, raising the anticoagulant activity of the blood, in combination with a genetically high activation threshold for the complement system may further contribute to the resistancy against thrombo-embolic disorders. Bleeding tendency, and susceptibility to infection disorders may be the possible draw-backs. Our data are framed into a hypothesis combining the indications of genetic predispositions and the evidence of exogenous protective factors, inflicting a coherent enhancement of nonsusceptibility to vascular ischemic catastrophies.