EMT and TGF-beta in renal fibrosis.
EMT and TGF-beta in renal fibrosis.
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DOI：
10.2741/s60
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发表时间：
2010
期刊：
影响因子：
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通讯作者：
M. Iwano
中科院分区：
文献类型：
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作者：
M. Iwano
转化生长因子-β 1（Transforming growth factor-beta1，TGF-β 1）是TGF-β超家族成员，是多种疾病中肾纤维化发生、发展的主要介质。TGF-β 1的一个关键作用是诱导上皮-间充质转化（EMT），这可能解释了组织纤维化进展期间成纤维细胞的持续补充。自从我们首次发现EMT是肾纤维化中成纤维细胞的起源以来，EMT相关的信号转导在肾脏学领域得到了广泛的研究。在过去的五年中，TGF-β 1诱导EMT的详细机制已被阐明，目前正在提出针对TGF-β 1介导的EMT的新治疗方法。
Transforming growth factor-beta1 (TGF-beta1) is a member of TGF-beta superfamily and the principal mediator contributing to the development and progression of renal fibrosis in a variety of disease settings. A critical effect of TGF-beta1 is the induction of epithelial-mesenchymal transition (EMT), which likely explains the continuous replenishment of fibroblasts during the progression of tissue fibrosis. Since we first identified EMT as the origin of fibroblasts in renal fibrosis, the signaling underlying EMT has been intensively studied in the field of nephrology. During the past five years, detailed mechanisms by which TGF-beta1 induces EMT have been clarified, and novel therapeutic approaches targeting TGF-beta1-mediated EMT are now being proposed.