DEVELOPMENT OF SEXUAL DIMORPHISM IN SYNAPTIC ORGANIZATION IN THE VENTROMEDIAL NUCLEUS OF THE HYPOTHALAMUS IN RATS
DEVELOPMENT OF SEXUAL DIMORPHISM IN SYNAPTIC ORGANIZATION IN THE VENTROMEDIAL NUCLEUS OF THE HYPOTHALAMUS IN RATS
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DOI：
10.1016/0304-3940(86)90135-7
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发表时间：
1986-07-24
影响因子：
2.5
通讯作者：
ARAI, Y
中科院分区：
文献类型：
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作者：
MATSUMOTO, A;ARAI, Y
对5日龄、20日龄、45日龄和100日龄雄性和雌性大鼠下丘脑腹内侧核(VMN)进行了超微结构观察。在前20天，VMN内的突触数目增加到45日龄时的70-80%。5日龄时，树突触和棘突的数密度无性别差异。20日龄时，性激素受体丰富的腹外侧侧VMN出现突触性别差异。这种倾向一直持续到成年。而背内侧VMN在突触模式上没有性别差异。这些结果表明，VMN内突触组织的性别二型性始于青春期前。
The ventromedial nuclei of the hypothalamus (VMN) were examined ultrastructurally in both male and female rats at 5, 20, 45 and 100 days of age. Synaptic number in the VMN was increased to 70-80% of that at 45 days of age during the first 20 days. At 5 days of age, sexual difference in the numerical density of dendritic shaft and spine synapses was not detected. Synaptic sexual difference developed by 20 days of age in the ventrolateral VMN where receptors for sex steroid were abundant. This tendency persisted until adulthood. However, no sexual difference in synaptic pattern was recognized in the dorsomedial VMN. From these results, it is suggested that sexual dimorphism in synaptic organization in the VMN develops from the early prepubertal period.