Trends in chronic opioid use and association with five-year survival in South Korea: a population-based cohort study
Trends in chronic opioid use and association with five-year survival in South Korea: a population-based cohort study
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DOI：
10.1016/j.bja.2019.08.012
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发表时间：
2019-11-01
影响因子：
9.8
通讯作者：
Choi, Jae Wook
中科院分区：
文献类型：
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作者：
Oh, Tak Kyu;Jeon, Young-Tae;Choi, Jae Wook
背景：韩国国民健康保险服务（NHIS）的目的是为医学研究提供人口数据。本研究的目的是估计处方阿片类药物的使用在韩国的趋势，并确定慢性阿片类药物的使用和5年的死亡率之间的关联在癌症和非癌症patients.Methods：一个基于人群的队列研究进行了韩国成年人口使用的数据从NHIS。那些连续供应类阿片超过90天的人被定义为长期类阿片使用者。多变量考克斯回归分析用于评估慢性阿片类药物使用与5年死亡率之间的关联。结果：慢性弱阿片类药物使用者的比例从2002年的1.03%增加到2015年的9.62%。长期强效阿片类药物使用者的比例从2002年的0.04%上升到2015年的0.24%。在2010年队列（n= 822214）中，与非使用者相比，长期弱阿片类药物使用者的5年死亡率显著降低（风险比[HR]：0.93; 95%置信区间[CI]：0.89-0.96; P
Background: The Korean National Health Insurance Service (NHIS) was developed to provide population data for medical research. The aim of this study was to estimate trends in prescription opioid use in South Korea, and to determine the association between chronic opioid use and 5-yr mortality in cancer and non-cancer patients.Methods: A population-based cohort study was conducted amongst the South Korean adult population using data from the NHIS. Those prescribed a continuous supply of opioids for >= 90 days were defined as chronic opioid users. Multi-variable Cox regression analysis was used to assess the association between chronic opioid use and 5-yr mortality.Results: The proportion of chronic weak opioid users increased from 1.03% in 2002 to 9.62% in 2015. The proportion of chronic strong opioid users increased from 0.04% in 2002 to 0.24% in 2015. In the 2010 cohort (n=822 214), compared with non-users, chronic weak opioid users had a significantly lower 5-yr mortality (hazard ratio [HR]: 0.93; 95% confidence interval [CI]: 0.89-0.96; P