Electrophysiological and psychophysical differences between early- and late-onset strabismic amblyopia
Electrophysiological and psychophysical differences between early- and late-onset strabismic amblyopia
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DOI：
10.1167/iovs.02-0240
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发表时间：
2003-02-01
影响因子：
4.4
通讯作者：
Holder, GE
中科院分区：
文献类型：
--
作者：
Davis, AP;Sloper, JJ;Holder, GE
目的.比较早发性和迟发性斜视性弱视成人的视觉诱发电位（VEP）和对比敏感度。12名成人早发性斜视性弱视和12名晚发性斜视性弱视，视力范围相似。在一系列对比度水平下记录到30分钟检查的模式发作VEP。对比敏感度（CS）在3.2周/度下使用双选择，强制选择阶梯法测量。早发组在所有对比度水平上，弱视眼和对侧眼之间的VEP CII潜伏期或振幅无显著差异，但在晚发组中，弱视眼的CH潜伏期明显较长，振幅较小。早发性弱视患者的CH反应潜伏期和波幅均明显短于正常人，对侧眼也明显短于正常人。迟发性弱视组CH反应潜伏期较正常组明显延长，波幅较正常组明显降低，而对侧眼反应潜伏期和波幅与正常组无明显差异。迟发性弱视表现为弱视眼中央视野的CS降低，但对侧眼的CS较正常眼增加。在早发组中，弱视眼和对侧眼或正常眼的中央CS没有差异。早发性和晚发性斜视性弱视的电生理和心理物理特征存在显著差异。
PURPOSE. To compare visual evoked potentials (VEPs) and contrast sensitivity in adults with early- or late-onset strabismic amblyopia.METHODS. Twelve adults with early- and 12 with late-onset strabismic amblyopia with similar ranges of visual acuity were studied. Pattern-onset VEPs to 30-minute checks were recorded at a range of contrast levels. Contrast sensitivity (CS) was measured at 3.2 cyc/deg using a two-alternative, forced-choice staircase method.RESULTS. There was no significant difference in VEP CII latency or amplitude between amblyopic and fellow eyes across all contrast levels for the early-onset group, but in the late-onset group, CH latencies were significantly longer and amplitudes smaller in the amblyopic eye. CH responses in both amblyopic and fellow eyes of the early-onset amblyopes were of significantly shorter latency and smaller amplitude than normal. In the late-onset group the CH responses from the amblyopic eye were of significantly increased latency and reduced amplitude compared with normal, whereas latency and amplitude of fellow eye responses did not differ significantly from normal. Late-onset amblyopes showed reduced CS across the central field for the amblyopic eye, but increased CS for the fellow eye compared with normal. In the early-onset group, central CS did not differ between amblyopic and fellow eyes or from normal.CONCLUSIONS. There are significant differences in the electro-physiological and psychophysical characteristics of adults with early- and late-onset strabismic amblyopia.