Effect of the recombinant vaccinia viruses that express HTLV‐I envelope gene on HTLV‐I infection.
Effect of the recombinant vaccinia viruses that express HTLV‐I envelope gene on HTLV‐I infection.
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表达HTLV-I包膜基因的重组牛痘病毒对HTLV-I感染的影响。
作者：
H. Shida;T. Tochikura;T. Sato;T. Konno;K. Hirayoshi;M. Seki;Y. Ito;M. Hatanaka;Y. Hinuma;M. Sugimoto
人类 T 淋巴细胞病毒 I 型 (HTLV-I) 在病因学上与成人 T 细胞白血病 (ATL) 有关。为了开发针对 ATL 的疫苗，我们构建了重组痘苗病毒，其痘苗病毒血凝素 (HA) 基因中含有 HTLV-I 包膜基因，这是一个可以插入外源基因的新位点。重组病毒单次接种可诱导家兔产生针对 HTLV-I env 蛋白的抗体，并对 HTLV-I 感染具有保护作用。
The human T‐lymphotropic virus type I (HTLV‐I) is etiologically linked to adult T‐cell leukemia (ATL). To develop a vaccine against ATL, we constructed recombinant vaccinia viruses containing the envelope gene of HTLV‐I in the vaccinia virus hemagglutinin (HA) gene, a new site where foreign genes can be inserted. A single inoculation of the recombinant virus induced antibodies to the env proteins of HTLV‐I in rabbits and had a protective effect against HTLV‐I infection.