Terahertz spectroscopy of brain tissue from a mouse model of Alzheimer's disease
Terahertz spectroscopy of brain tissue from a mouse model of Alzheimer's disease
复制标题
DOI：
10.1117/1.jbo.21.1.015014
复制
发表时间：
2016-01-01
影响因子：
3.5
通讯作者：
Alfano, Robert
中科院分区：
文献类型：
--
作者：
Shi, Lingyan;Shumyatsky, Pavel;Alfano, Robert
采用太赫兹时域光谱法（THz-TDS）比较了阿尔茨海默病（AD）小鼠模型和对照野生型（正常）小鼠脑组织的太赫兹（THz）吸收和折射率。在AD组织中观察到与扭转振动模式相关的三个主要吸收峰，在约1.44、1.8和2.114 THz处，比正常组织更接近游离色氨酸分子的峰。一个可能的原因是，在AD脑组织中有更多的游离色氨酸，而在正常脑组织中，更多的色氨酸附着在其他分子上。我们的研究表明，太赫兹吸收模式可以作为一个AD生物标志物指纹在大脑中，太赫兹TDS是一个有前途的技术，用于早期诊断AD。(C)2016年，美国光电仪器工程师学会（SPIE）
The terahertz (THz) absorption and index of refraction of brain tissues from a mouse model of Alzheimer's disease (AD) and a control wild-type (normal) mouse were compared using THz time-domain spectroscopy (THz-TDS). Three dominating absorption peaks associated to torsional-vibrational modes were observed in AD tissue, at about 1.44, 1.8, and 2.114 THz, closer to the peaks of free tryptophan molecules than in normal tissue. A possible reason is that there is more free tryptophan in AD brain tissue, while in normal brain tissue more tryptophan is attached to other molecules. Our study suggests that THz-absorption modes may be used as an AD biomarker fingerprint in brain, and that THz-TDS is a promising technique for early diagnosis of AD. (C) 2016 Society of Photo-Optical Instrumentation Engineers (SPIE)