Cross-Reactive Antibody Responses to the 2009 Pandemic H1N1 Influenza Virus.
Cross-Reactive Antibody Responses to the 2009 Pandemic H1N1 Influenza Virus.
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DOI：
10.1056/nejmoa0906453
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发表时间：
2009-11-12
影响因子：
158.5
通讯作者：
Katz, Jacqueline M.
中科院分区：
文献类型：
--
作者：
Hancock, Kathy;Veguilla, Vic;Katz, Jacqueline M.
背景：一种新的大流行性流感A（H1N1）病毒已经出现，在全球范围内引起疾病，主要是在较年轻的年龄组。为了评估人类已有免疫力的水平，并评估季节性疫苗接种策略，我们测量了不同年龄组中因既往流感感染或接种疫苗而产生的对大流行病毒的抗体应答。方法：使用微量中和试验，我们测量了H1N1流感病毒的交叉反应抗体，来自献血者或接种过最近季节性或1976年猪流感疫苗的人的储存血清样本中检测到2009年H1N1流感病毒。结果：1980年以后出生的107人中有4人（4%）对2009年H1N1的交叉反应抗体滴度为40或更高，而1950年以前出生的115人中有39人（34%）的滴度为80或更高。接种季节性三价灭活流感疫苗导致55名6个月至9岁的儿童中没有一人的2009 H1N1交叉反应抗体水平增加4倍或更多，231名18至64岁的成年人中有12%至22%，在113名60岁或以上的成年人中，有5%或更少。用佐剂配制的季节性疫苗没有进一步增强交叉反应性抗体应答。接种A/新泽西/1976年猪流感疫苗大大提高了交叉反应性抗体2009 H1N1在adults.Conclusions：最近的季节性nonadjuvanted或adjuvanted流感疫苗接种诱导很少或没有交叉反应性抗体反应2009 H1N1在任何年龄组。30岁以下的人几乎没有证据表明对大流行性病毒有交叉反应抗体。然而，一部分老年人预先存在交叉反应性抗体。N Engl J Med 2009;361：1945-52。
Background: A new pandemic influenza A (H1N1) virus has emerged, causing illness globally, primarily in younger age groups. To assess the level of preexisting immunity in humans and to evaluate seasonal vaccine strategies, we measured the antibody response to the pandemic virus resulting from previous influenza infection or vaccination in different age groups.Methods: Using a microneutralization assay, we measured cross-reactive antibodies to pandemic H1N1 virus (2009 H1N1) in stored serum samples from persons who either donated blood or were vaccinated with recent seasonal or 1976 swine influenza vaccines.Results: A total of 4 of 107 persons (4%) who were born after 1980 had preexisting cross-reactive antibody titers of 40 or more against 2009 H1N1, whereas 39 of 115 persons (34%) born before 1950 had titers of 80 or more. Vaccination with seasonal trivalent inactivated influenza vaccines resulted in an increase in the level of cross-reactive antibody to 2009 H1N1 by a factor of four or more in none of 55 children between the ages of 6 months and 9 years, in 12 to 22% of 231 adults between the ages of 18 and 64 years, and in 5% or less of 113 adults 60 years of age or older. Seasonal vaccines that were formulated with adjuvant did not further enhance cross-reactive antibody responses. Vaccination with the A/New Jersey/1976 swine influenza vaccine substantially boosted cross-reactive antibodies to 2009 H1N1 in adults.Conclusions: Vaccination with recent seasonal nonadjuvanted or adjuvanted influenza vaccines induced little or no cross-reactive antibody response to 2009 H1N1 in any age group. Persons under the age of 30 years had little evidence of cross-reactive antibodies to the pandemic virus. However, a proportion of older adults had preexisting cross-reactive antibodies.N Engl J Med 2009;361:1945-52.