Systematic Analysis of Translocator Protein 18 kDa (TSPO) Ligands on Toll-like Receptors-mediated Pro-inflammatory Responses in Microglia and Astrocytes.
Systematic Analysis of Translocator Protein 18 kDa (TSPO) Ligands on Toll-like Receptors-mediated Pro-inflammatory Responses in Microglia and Astrocytes.
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DOI：
10.5607/en.2016.25.5.262
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发表时间：
2016-10
影响因子：
2.4
通讯作者：
Yu SW
中科院分区：
文献类型：
--
作者：
Lee JW;Nam H;Yu SW
易位蛋白 18 kDa (TSPO) 是一种在反应性小胶质细胞和星形胶质细胞上高表达的线粒体蛋白，被认为是神经退行性和脑损伤（尤其是神经炎症）的生物标志物。 Toll样受体（TLR）与小胶质细胞和星形胶质细胞的炎症反应密切相关，这些信号通路调节神经炎症。之前的报道已经确定了 TSPO 配体的抗炎作用，但对其与 TLR 信号传导相关的作用的研究有限。在这里，我们研究了五种代表性 TSPO 配体在被各种 TLR 配体激活后对小胶质细胞和星形胶质细胞的影响。我们的结果表明，TSPO 配体减少了 TLR 配体引起的促炎反应，对小胶质细胞的影响比星形胶质细胞更深远。
Translocator protein 18 kDa (TSPO) is a mitochondrial protein highly expressed on reactive microglia and astrocytes, and is considered as a biomarker for neurodegeneration and brain damage, especially neuroinflammation. Toll-like receptors (TLRs) are closely related with inflammatory responses of microglia and astrocytes and these signaling pathways regulate neuroinflammation. Previous reports have identified the anti-inflammatory effects of TSPO ligands, however study of their effects in relation to the TLR signaling was limited. Here, we investigated the effects of five representative TSPO ligands on microglia and astrocytes following activation by various TLR ligands. Our results show that TSPO ligands reduce the pro-inflammatory response elicited by the TLR ligands with more profound effects on microglia than astrocytes.
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影响因子：
4.6
作者：
Daugherty DJ;Chechneva O;Mayrhofer F;Deng W
通讯作者：
Deng W
影响因子：
1.2
作者：
Schildge, Sebastian;Bohrer, Christian;Schachtrup, Christian
通讯作者：
Schachtrup, Christian
影响因子：
1.2
作者：
Tamashiro, Tami T.;Dalgard, Clifton Lee;Byrnes, Kimberly R.
通讯作者：
Byrnes, Kimberly R.
DOI：
10.1016/j.bbrc.2016.04.080
发表时间：
2016-06-03
影响因子：
3.1
作者：
Lee, Ji-Won;Kim, Leah Eunjung;Yu, Seong-Woon
通讯作者：
Yu, Seong-Woon
影响因子：
6.2
作者：
Veiga, Sergio;Carrero, Paloma;Garcia-Segural, Luis Miguel
通讯作者：
Garcia-Segural, Luis Miguel