Effects of stimulation of nucleus ambiguus complex on gastroduodenal function.
Effects of stimulation of nucleus ambiguus complex on gastroduodenal function.
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刺激疑核复合体对胃十二指肠功能的影响。
DOI：
10.1152/ajpgi.1984.246.3.g253
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发表时间：
1984
期刊：
影响因子：
--
通讯作者：
Gillis,RA
中科院分区：
文献类型：
--
作者：
Pagani,FD;Norman,WP;Kasbekar,DK;Gillis,RA
本实验观察了电刺激疑核复合体对α-氯醛糖麻醉猫胃十二指肠运动和胃分泌的影响。通过使用缝合到身体、胃窦、幽门和十二指肠的腔外力传感器来测量运动能力。通过测定胃液pH值、可滴定酸度和胃蛋白酶原活性的变化来测量分泌量。刺激NA复合体(11只动物右侧NA，8只动物左侧NA)可引起胃窦、幽门和十二指肠收缩，以及窦性心动过缓和低血压，刺激参数为133微安、50赫兹和0.2ms脉冲持续时间。电刺激NA复合体引起的运动和心血管反应均可通过同侧迷走神经切断术加以预防。诱发胃十二指肠运动增加的最佳刺激频率为50赫兹。高于50赫兹的频率会导致运动反应减弱。心率反应并非如此，因为窦性心动过缓在10赫兹时最大，并维持在100赫兹。电刺激NA复合体(8只动物)对胃蛋白酶原的分泌和可滴定的酸度没有影响，但产生少量的(0.21个pH单位)但显著增加胃的pH。这些结果表明：1)刺激NA复合体导致同侧迷走神经介导的运动性显著增加，2)介导这些运动性反应的通路似乎比介导心脏运动反应的通路涉及更多的突触。
We investigated the effects of stimulation of the nucleus ambiguus (NA) complex on gastroduodenal motility and gastric secretion in alpha-chloralose-anesthetized cats. Motility was measured by use of extraluminal force transducers sutured to the body, antrum, pylorus, and duodenum. Secretion was measured by determining changes in gastric pH, titratable acidity, and pepsinogen activity. Stimulation of the NA complex (right NA in 11 animals and left NA in 8 animals) elicited contractions of the antrum, pylorus, and duodenum, as well as sinus bradycardia and hypotension using stimulus parameters of 133 microA, 50 Hz, and 0.2-ms pulse duration. Both the motility and cardiovascular responses evoked by electrical stimulation of the NA complex were prevented by ipsilateral vagotomy. The optimum stimulus frequency for eliciting increases in gastroduodenal motility was 50 Hz. Frequencies higher than 50 Hz resulted in attenuated motility responses. This was not true of the heart rate response, as sinus bradycardia was maximal at 10 Hz and was maintained to 100 Hz. Electrical stimulation of the NA complex (8 animals) had no effect on pepsinogen secretion or titratable acidity, but produced a small (0.21 pH units) but significant increase in gastric pH. These results indicate that 1) stimulation of the NA complex results in pronounced increases in motility mediated by the ipsilateral vagus nerve, and 2) the pathways mediating these motility responses appear to involve more synapses than the pathways mediating the motor responses to the heart.