Clinical outcomes of expiratory muscle training in severe COPD patients
Clinical outcomes of expiratory muscle training in severe COPD patients
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DOI：
10.1016/j.rmed.2006.06.024
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发表时间：
2007-03-01
影响因子：
4.3
通讯作者：
Sanchis, Joaquin
中科院分区：
文献类型：
--
作者：
Mota, Susana;Guell, Rosa;Sanchis, Joaquin
慢性阻塞性肺疾病(COPD)患者最常见的症状是呼吸困难和运动受限。目的：探讨呼气训练对重度COPD患者肺功能、运动耐量、症状和健康相关生活质量的影响。方法：16例患者(FEV1，28+/-8%pred)。受试者被随机分为呼气肌肉训练组或假训练组，两组均完成为期5周的训练(每周3次，每次30分钟)(分别为最大呼气压力(MEP)的50%与安慰剂组)。在训练前和训练结束后评估肺功能、运动能力(自行车测功术和步行试验)、临床结果(呼吸困难和生活质量(圣乔治呼吸问卷))。结果：虽然训练后肺功能基本保持不变，但运动能力、症状和生活质量明显改善。步行距离和SGRQ评分的改善与MER的变化显著相关。结论：我们的结果证实，门诊短时间的呼气训练可以改善重症COPD患者的症状和生活质量。这些影响可以部分解释为呼气肌肉力量的变化。(C)2006爱思唯尔有限公司。保留所有权利。
The most common symptoms in chronic obstructive pulmonary disease (COPD) patients are breathlessness and exercise limitation. Although both general and inspiratory muscle training have shown clinical benefits, the effects of specific expiratory muscle training remain controversial.Objective: To investigate the effects of expiratory training on lung function, exercise tolerance, symptoms and health-related quality of life in severe COPD patients.Methods: Sixteen patients (FEV1, 28 +/- 8% pred.) were randomised to either expiratory muscle or sham training groups, both completing a 5-week programme (30min sessions breathing through an expiratory threshold valve 3 times per week) (50% of their maximal expiratory pressure (MEP) vs. placebo, respectively). Lung function, exercise capacity (bicycle ergometry and walking test), and clinical outcomes (dyspnoea and quatity of life (St. George Respiratory Questionnaire (SGRQ)) were evaluated both at baseline and following the training period.Results: Although lung function remained roughly unchanged after training, exercise capacity, symptoms and quality of life significantly improved. The improvement in both walking distance and the SGRQ score significantly correlated with changes in MERConclusion: Our results confirm that a short outpatient programme of expiratory training can improve symptoms and quality of life in severe COPD patients. These effects could be partially explained by changes in expiratory muscle strength. (c) 2006 Elsevier Ltd. All rights reserved.