Stimulation threshold of isolated myocytes and cross shock defibrillation
Stimulation threshold of isolated myocytes and cross shock defibrillation
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离体肌细胞的刺激阈值和交叉电击除颤
DOI：
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发表时间：
1988
期刊：
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通讯作者：
J. Chesnais
中科院分区：
文献类型：
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作者：
A. Bardou;J. Degonde;P. Birkui;J. Chesnais
以前的研究结果表明，心脏纤维刺激阈值可能依赖于刺激电轴方向。这项工作的目的是证明这种现象的分离心肌细胞。将细胞置于培养箱中，在培养箱中，细胞自发地沿沿着多个方向排列。刺激脉冲在两个平行电极之间传递，强度逐渐增加，直到细胞收缩。这种收缩总是最先从受到纵向刺激最多的肌细胞获得。然后通过增加强度观察到渐进性募集，获得最垂直的肌细胞收缩，其值约为刺激纵向收缩所需值的两倍。这清楚地表明，正交冲击使用所需的最低能量使所有心脏纤维去纤维化。<<ETX>>
Results of a previous study suggested the possible dependence of heart-fiber stimulation threshold on the stimulus electric axis orientation. The aim of this work has been to demonstrate this phenomenon on isolated cardiomyocytes. The cells were placed in a culture box where they appeared spontaneously arranged along multiple directions. Stimulation pulses were delivered between two parallel electrodes, increasing progressively in intensity until the cells contracted. This contraction was always obtained for the most longitudinally stimulated myocytes first. Progressive recruitment was then observed by increasing the intensity, the most perpendicular myocyte contraction being obtained for a value approximately double that necessary to stimulate the longitudinal ones. This clearly shows that orthogonal shocks depolarize all heart fibers using the lowest energy required.<<ETX>>