Characterization of tracheal mast cell reactions in vivo. Inhibition by a beta-adrenergic agonist.
Characterization of tracheal mast cell reactions in vivo. Inhibition by a beta-adrenergic agonist.
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体内气管肥大细胞反应的表征。
DOI：
10.1164/arrd.1982.126.5.842
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发表时间：
1982
期刊：
影响因子：
--
通讯作者：
Gold,WM
中科院分区：
文献类型：
--
作者：
Brown,JK;Leff,AR;Frey,MJ;Reed,BR;Lazarus,SC;Shields,R;Gold,WM
在 12 只麻醉狗中，我们测试了药理学 β-肾上腺素能刺激对体内气管肥大细胞反应严重程度的影响（Am Rev Respir Dis 1979；119:62）。在对照犬中，气管动脉注射化合物 48/80 会产生气管内组胺浓度的动静脉差异 (35 ± 15 ng/ml)，但肺部不会产生差异；这一发现表明气管肥大细胞选择性脱粒。在这些动物中，气管动静脉组胺差异与化合物 48/80 诱导的气管收缩 (12 ± 4 g/cm) 相关 (r = 0.70)。在其他狗中，在化合物 48/80 之前注射异丙肾上腺素 (10 μg/kg) 可防止气管动静脉差异和收缩的发生。我们得出结论，药理学β-肾上腺素能刺激抑制气管肥大细胞脱粒。该制剂似乎适合检查内源性刺激对麻醉犬中央气道肥大细胞反应严重程度的影响。
In 12 anesthetized dogs, we tested the effects of pharmacologic beta-adrenergic stimulation on the severity of tracheal mast cell reactionsin vivo(Am Rev Respir Dis 1979; 119:62). In control dogs, tracheal arterial injections of compound 48/80 produced arteriovenous differences in histamine concentrations across the trachea (35 ± 15 ng/ml), but not the lung; this finding suggested selective degranulation of tracheal mast cells. Tracheal arteriovenous histamine differences correlated (r = 0.70) with tracheal contractions (12 ± 4 g/cm) induced by compound 48/80 in these animals. In other dogs, injections of isoproterenol (10 μg/kg) before compound 48/80 prevented the development of both tracheal arteriovenous differences and contractions. We concluded that pharmacologic beta-adrenergic stimulation inhibited degranulation of tracheal mast cells. The preparation appears suitable for examining the effects of endogenous stimuli on the severity of mast cell reactions in the central airways of anesthetized dogs.