The role of intracerebral dopamine D1 and D2 receptors in sleep-wake cycles and general anesthesia.
The role of intracerebral dopamine D1 and D2 receptors in sleep-wake cycles and general anesthesia.
复制标题
脑内多巴胺 D1 和 D2 受体在睡眠-觉醒周期和全身麻醉中的作用
DOI：
10.1002/ibra.12024
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发表时间：
2022
期刊：
影响因子：
--
通讯作者：
Zhang, Yi
中科院分区：
文献类型：
--
作者：
Zhang, Jie;Li, Jia;Liu, Cheng-Xi;Gui, Huan;Yuan, Cheng-Dong;Zhang, Yi
摘要多巴胺(DA)是一种单胺类神经递质，主要由中脑腹侧被盖区和黑质致密部神经元合成和释放。DA及其受体对觉醒、运动、认知、奖赏和其他神经生物学行为的调节是必不可少的。唤醒、运动、认知、奖励和其他神经生物学功能都受多巴胺及其受体的调节。多巴胺受体可分为类D_1受体(包括D_1和D_5)和类D_2受体(包括D_2、D_3和D_4)，其中D_1和D_2受体(D_1Rs和D_2Rs)最为重要。目前，研究表明D1Rs和D2Rs与睡眠-觉醒和全身麻醉过程密切相关，但具体机制尚不清楚。本文综述了D1Rs和D2Rs在中枢神经系统中的结构、分布和信号通路，以及D1Rs和D2Rs在睡眠觉醒和全身麻醉中的作用。因此，对D1Rs和D2Rs的研究不仅有助于更好地了解睡眠-觉醒控制的工作原理，而且有助于了解全身麻醉的机制。
Abstract Dopamine (DA), a monoamine neurotransmitter, is synthesized and released mainly by neurons in the ventral tegmental area and the substantia nigra (SN) pars compacta of the midbrain. DA and its receptors are essential for the regulation of arousal, movement, cognition, reward, and other neurobiological behaviors. Arousal, locomotion, cognition, reward, and other neurobiological functions are all regulated by dopamine and its receptors. Dopamine receptors can be divided into D1‐like receptors (including D1 and D5) or D2‐like receptors (containing D2, D3, and D4), with D1 and D2 receptors (D1Rs, and D2Rs) being the most important. Currently, studies indicated that D1Rs and D2Rs are tightly involved with the process of sleep‐wake and general anesthesia, but the specific mechanism remains unclear. In this review, we compiled the most recent findings, mainly focusing on the structure, distribution, and signal pathway of D1Rs and D2Rs in the central nervous system, as well as the involvement of D1Rs and D2Rs in sleep‐wake and general anesthesia. Thus, the investigations of the D1Rs and D2Rs will benefit not only better knowledge for how sleep‐wake control works but also the mechanism of general anesthesia.