DERMAL-EPIDERMAL INTERACTIONS - FOLLICLE-DERIVED CELL-POPULATIONS IN THE STUDY OF HAIR-GROWTH MECHANISMS
DERMAL-EPIDERMAL INTERACTIONS - FOLLICLE-DERIVED CELL-POPULATIONS IN THE STUDY OF HAIR-GROWTH MECHANISMS
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DOI：
10.1111/1523-1747.ep12362577
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发表时间：
1993-07-01
影响因子：
6.5
通讯作者：
REYNOLDS, AJ
中科院分区：
文献类型：
--
作者：
JAHODA, CAB;REYNOLDS, AJ
所有皮肤附属物的发育都是由一系列真皮与表皮的相互作用开始的。这些继续通过专门的毛囊细胞群来支持成人毛囊的活动-事实上，从成人毛囊中分离的真皮乳头的诱导特性已经很好地建立起来。对于成人毛囊表皮对真皮细胞的影响，或者其他毛囊类型的乳头细胞的诱导特性，我们所知甚少。不同寻常的是，培养的乳头细胞能够在培养过程中支持皮肤表皮细胞的增殖，但不能产生更复杂的组织或分化。然而，来自卵泡基部的萌发性表皮细胞在形态和行为上与其他表皮细胞群不同，它们与乳头细胞简单结合，相互作用形成具有独特基底层的复杂结构。毛囊萌发细胞对真皮细胞有重要的影响，这一点在体内重组中得到了进一步证明，在体内重组中，萌发细胞与其他非诱导毛囊真皮鞘细胞相互作用，启动毛囊形成和毛发生长。在体外，几个毛囊细胞群聚集在毛囊囊内，并在三维培养系统中生长，产生毛发型纤维。在控制条件下，将培养的表皮毛囊真皮乳头细胞单独植入足垫皮肤，可诱导出新的表皮毛囊和纤维。这强调了乳头细胞诱导影响的力量和普遍性，并强调了细胞操作的皮肤病学潜力。脚垫表皮的转分化是一种强大的生物学现象，通常只在胚胎型联合实验中看到。
All skin appendage development is initiated by a series of dermal-epidermal interactions. These continue to underpin adult hair follicle activities through the specialized follicular cell populations - indeed the inductive properties of isolated dermal papillae from adult vibrissa follicles are well established. Far less is known about the influence of adult follicle epidermis on dermal cells, or inductive properties of papilla cells from other follicle types.Cultured papilla cells, unusually, are able to support the proliferation of skin epidermal cells during simple association in culture, but do not produce more elaborate organization or differentiation. However, germinative epidermal cells from the follicle base are morphologically and behaviorally distinct from other epidermal populations, and in simple association with papilla cells interact to form complex structures with a distinct basal lamina. That hair follicle germinative cells have an important influence on dermal cells is further demonstrated by in vivo recombinations, where germinative cells interact with otherwise non-inductive follicle dermal sheath cells to initiate follicle formation and hair growth.In vitro, several follicle cell populations assembled within the capsule of a vibrissa follicle and grown in a three-dimensional culture system produce hair-type fibers. When cultured pelage follicle dermal papilla cells are implanted alone into footpad skin under controlled conditions, new pelage-type follicles and fibers are induced. This emphasizes the power and universal nature of inductive influences from papilla cells, and underlines the dermatologic potential of cell manipulations. The transdifferentiation of the footpad epidermis is a powerful biologic phenomenon normally only seen in embryonic-type association experiments.