Derivation of Endodermal Progenitors From Pluripotent Stem Cells.
Derivation of Endodermal Progenitors From Pluripotent Stem Cells.
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DOI：
10.1002/jcp.24771
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发表时间：
2015-02
影响因子：
5.6
通讯作者：
Kotton, Darrell N.
中科院分区：
文献类型：
--
作者：
Ikonomou, Laertis;Kotton, Darrell N.
干细胞和祖细胞在发育过程中的器官形成以及出生后的组织稳态和对损伤的反应中起重要作用。由于许多人体组织的再生能力有限，细胞替代疗法对人类疾病管理具有很大的希望。多能干细胞如胚胎干（ES）细胞和诱导多能干（iPS）细胞是通过开发定向分化方案（即，体外细胞培养中发育里程碑的重演）来衍生无限量的临床相关细胞类型的主要候选者。组织特异性祖细胞，包括内胚层来源的祖细胞，是这些方案中的重要中间体，因为它们产生所有成熟的实质细胞。本文就胚胎内胚层祖细胞的关键转录因子和信号通路的体内生物学研究进展作一综述。我们批判性地回顾了新兴的文献，旨在应用这些基本知识，以实现有效的和可重复的内胚层祖细胞，如胰腺，肝脏和肺前体细胞的体外衍生。
Stem and progenitor cells play important roles in organogenesis during development and in tissue homeostasis and response to injury postnatally. As the regenerative capacity of many human tissues is limited, cell replacement therapies hold great promise for human disease management. Pluripotent stem cells such as embryonic stem (ES) cells and induced pluripotent stem (iPS) cells are prime candidates for the derivation of unlimited quantities of clinically relevant cell types through development of directed differentiation protocols, i.e. the recapitulation of developmental milestones in in vitro cell culture. Tissue-specific progenitors, including progenitors of endodermal origin, are important intermediates in such protocols since they give rise to all mature parenchymal cells. In this review, we focus on the in vivo biology of embryonic endodermal progenitors in terms of key transcription factors and signaling pathways. We critically review the emerging literature aiming to apply this basic knowledge to achieve the efficient and reproducible in vitro derivation of endodermal progenitors such as pancreas, liver and lung precursor cells.
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发表时间：
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