Tissue factor activity and function in blood coagulation
Tissue factor activity and function in blood coagulation
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DOI：
10.1016/s0049-3848(08)70018-5
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发表时间：
2008-01-01
影响因子：
7.5
通讯作者：
Mann, Kenneth G.
中科院分区：
文献类型：
--
作者：
Butenas, Saulius;Orfeo, Thomas;Mann, Kenneth G.
组织因子（TF）是血液凝固的主要生理启动因子。它作为一种完整的膜蛋白存在，在血管损伤时暴露于血流并引发一系列导致血液凝结的酶促反应。TF也存在于循环血细胞中，需要特定的信号事件来促进其表达。在这篇综述中，我们将讨论目前的争议有关TF的结构-活性关系和TF的止血过程中的贡献，血管内TF的潜在作用，包括非细胞结合的TF和细胞表达的TF和TF功能和出血控制之间的整体关系。(c)2008爱思唯尔有限公司保留所有权利。
Tissue factor (TF) is the major physiological initiator of blood coagulation. It exists as an integral membrane protein that upon injury to the blood vessel becomes exposed to the blood stream and initiates a series of enzymatic reactions that cause blood to clot. TF is also found within circulating blood cells, requiring specific signaling events to promote its expression. In this review we will discuss current controversies concerning the structure-activity relationships of TF and contributions of TF to the hemostatic process, the potential roles of intravascular TF, including non-cell-bound TF and cell-expressed TF and the overall relationship between TF function and hemorrhage control. (c) 2008 Elsevier Ltd. All rights reserved.