Prospective randomized trial of one-hour sequential versus simultaneous methotrexate plus 5-fluorouracil in advanced and recurrent squamous cell head and neck cancer.
Prospective randomized trial of one-hour sequential versus simultaneous methotrexate plus 5-fluorouracil in advanced and recurrent squamous cell head and neck cancer.
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一小时序贯与同时甲氨蝶呤加 5-氟尿嘧啶治疗晚期和复发性鳞状细胞头颈癌的前瞻性随机试验。
DOI：
10.1200/jco.1983.1.12.787
复制
发表时间：
1983
期刊：
影响因子：
--
通讯作者：
M. Levine
中科院分区：
文献类型：
--
作者：
G. Browman;S. Archibald;J. Young;W. Hryniuk;R. Russell;K. Kiehl;M. Levine
Results from experimental systems suggest that the combination of methotrexate (MTX) and 5-fluorouracil (5-FU) produces synergistic cytotoxic effects that are dependent on the sequence of drug administration. Biochemical studies have demonstrated plausible mechanisms of a synergistic effect when MTX precedes 5-FU. A variety of phase I and phase II studies have employed this sequential combination with promising but inconclusive results. In this study, 79 evaluable patients with squamous cell head and neck cancer were randomized to receive MTX (200 mg/m2 IV) and 5-FU (600 mg/m2 IV) either simultaneously or sequentially with MTX preceding 5-FU by one hour. All patients were ambulatory and patients were stratified as to whether they presented with primary disease or with recurrence after prior radiation and/or surgical therapy. The overall response rate was superior for simultaneous therapy (62%) compared with sequential therapy (38%) (p less than 0.06). Among patients with primary head and neck cancer, the stage of the disease influenced the response rate. Eight of nine stage III patients who received simultaneous therapy responded while none of the four patients who received sequential therapy responded (p less than 0.01). This study demonstrates that one-hour sequential MTX plus 5-FU is not superior to simultaneous treatment in patients with squamous cell head and neck cancer.
甲氨蝶呤和 5-氟尿嘧啶在人结肠和乳腺肿瘤细胞系中的时间表依赖性细胞毒性。
DOI：
10.1172/jci109946
发表时间：
1980
期刊：
The Journal of clinical investigation
影响因子：
--
作者：
Benz,C;Schoenberg,M;Choti,M;Cadman,E
通讯作者：
Cadman,E
抗代谢物预处理对人结直肠腺癌 HCT-8 中 5-氟尿嘧啶代谢和细胞毒性的调节。
影响因子：
11.2
作者：
Benz,C;Cadman,E
通讯作者：
Cadman,E
甲氨蝶呤和二氢叶酸聚谷氨酸盐在甲氨蝶呤增强氟尿嘧啶作用中的作用。
DOI：
--
发表时间：
1981
期刊：
Cancer treatment reports
影响因子：
--
作者：
Fernandes,DJ;Moroson,BA;Bertino,JR
通讯作者：
Bertino,JR