Time-action profiles of insulin detemir in normal and diabetic dogs
Time-action profiles of insulin detemir in normal and diabetic dogs
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DOI：
10.1016/j.rvsc.2010.07.001
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发表时间：
2011-06-01
影响因子：
2.4
通讯作者：
Arai, T.
中科院分区：
文献类型：
--
作者：
Sako, T.;Mori, A.;Arai, T.
地特胰岛素是一类新的长效可溶胰岛素类似物中的第一个成员，能够维持人体胰岛素的基础水平。在这项初步研究中，我们调查了地特胰岛素在正常和糖尿病犬中的时间作用曲线，因为地特胰岛素在犬身上的使用尚未确定。我们的研究使用了8只动物(3只正常犬和5只胰岛素依赖型糖尿病犬)。在正常血糖条件下，使用人工胰腺装置监测正常犬的地替米尔胰岛素的时间-作用曲线。胰岛素依赖型糖尿病犬喂饲胰岛素后，每隔2小时采血一次。在正常狗身上的时间-作用曲线显示，地特胰岛素是一种与在人类中观察到的相似的长效制剂。在注射胰岛素后8~10h有一个明显的降糖高峰，降糖作用持续24 h以上，说明其峰值活动时间延长。此外，在胰岛素依赖型糖尿病犬中，使用比NPH胰岛素和甘精胰岛素治疗剂量更低的地特米尔胰岛素可以实现强化的血糖控制。我们的结果表明，地特胰岛素对犬有比NPH胰岛素或甘精胰岛素更大的作用，所需剂量比任何一种胰岛素制剂都要小。然而，与NPH胰岛素或甘精胰岛素相比，使用地特胰岛素也具有更高的诱导低血糖风险。(C)2010爱思唯尔有限公司。保留所有权利。
Insulin detemir is the first member of a new class of long-acting soluble insulin analogues capable of maintaining the basal level of insulin in humans. In this preliminary study, we investigated the timeaction profiles of insulin detemir in normal and diabetic dogs since the use of insulin detemir in canines has yet to be determined. Eight animals were used in our study (three normal and five insulin dependent diabetic dogs). Time-action profiles of insulin detemir were monitored in normal dogs using an artificial pancreas apparatus under euglycemic condition. Blood sampling was performed at 2 h intervals post feeding, with insulin administration, in insulin dependent diabetic dogs. Time-action profiles of insulin detemir, in normal dogs, demonstrated that insulin detemir is a long-lasting preparation similar to what has been observed in humans. A pronounced peak was detected at 8-10 h while the glucose-lowering effect lasted for over 24 h after insulin injection, thus illustrating its longer prolonged peak activity time. Furthermore, intensive glycemic control was achieved with insulin detemir in insulin dependent diabetic dogs, using a lower dosage than NPH insulin and insulin glargine therapeutic doses. Our results indicate that insulin detemir has a greater effect than either NPH insulin or insulin glargine in canines, requiring a lower dose than either insulin preparation. However, using insulin detemir also carries a higher risk of inducing hypoglycemia as compared to either NPH insulin or insulin glargine. (C) 2010 Elsevier Ltd. All rights reserved.