New processes for surface treatment of catheters.
New processes for surface treatment of catheters.
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导管表面处理的新工艺。
DOI：
10.1111/j.1525-1594.1994.tb02193.x
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发表时间：
1994
影响因子：
2.4
通讯作者：
Piran Sioshansi
中科院分区：
文献类型：
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作者：
Piran Sioshansi
感染、血栓形成和狭窄是接触血液的导管最常见的并发症之一，是由基质材料的表面特性引起的。基于离子束的工艺，如离子注入和离子束辅助沉积，只影响处理后材料表面的外部微米，对块体性能几乎没有影响。因此，这些工艺被用于常见的导管材料，并对它们的生物学特性进行了评估。离子注入材料，如硅橡胶，导致了更少的粘性，更多的湿润表面，在体内和初步的临床研究中都显示出抗血栓的能力。采用离子束辅助沉积的方法制备了银基涂层，体外和临床研究表明其具有抗菌活性。这些经过处理的导管材料的生物相容性也通过简单的实验室研究得到了证明。因此，这些过程可以很容易地应用于接触血液的导管，使其抗血栓和感染。
Infection, thrombosis, and stenosis are among the most common complications of blood-contacting catheters and are caused by surface properties of the substrate materials. Ion beam-based processes such as ion implantation and ion beam-assisted deposition affect only the outer micron of the treated material surface; there is little effect on bulk properties. These processes were therefore used on common catheter materials, and their biological properties were evaluated. Ion implantation of materials such as silicone rubber resulted in a less tacky, more wettable surface that demonstrated thrombus-resistance in both in vivo and preliminary clinical studies. Ion beam-assisted deposition was used to deposit silver-based coatings, which demonstrated antimicrobial activity in in vitro and clinical studies. Biocompatibility of these processed catheter materials was also demonstrated using simple laboratory studies. These processes, therefore, can be readily applied to blood-contacting catheters to make them thrombus- and infection-resistant.